ArticleScandinavian journal of trauma, resuscitation and emergency medicine2024
A national multi centre pre-hospital ECPR stepped wedge study; design and rationale of the ON-SCENE study.
Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04620070 (ON-SCENE Initiation of Extracorporeal CardioPulmonary Resuscitation), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ON-SCENE Initiation of Extracorporeal CardioPulmonary Resuscitation (ECPR) During Refractory Out-of-Hospital Cardiac Arrest
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Feasibility of implementing extracorporeal cardiopulmonary resuscitation in a middle-income country: systematic review and cardiac arrest case series.Critical care science · 2025Pooled it
- Endovascular resuscitation: an expert practice review.Emergency medicine journal : EMJ · 2026Review
- Modelling eCPR eligibility after out-of-hospital cardiac arrest: a 10-year retrospective temporospatial analysis from a mixed urban-rural region in Germany.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Article
- Clinical Significance of Helicopter Transportation for Patients With Acute Illness Admitted to Medical Intensive Care Unit.Circulation reports · 2026Article
- Accidental hypothermia.Nature reviews. Disease primers · 2026Review
- Ethics in prehospital extracorporeal cardiopulmonary resuscitation.Resuscitation plus · 2026Article
- Optimizing Regional Access to Extracorporeal Cardiopulmonary Resuscitation: A Geographic-Information-System-Based Comparison of Hospital- and Prehospital-Initiated Strategies in Nara Prefecture, Japan.Healthcare (Basel, Switzerland) · 2026Article
- Impact of transient return of spontaneous circulation and downtime on neurological outcomes following extracorporeal cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest: a single-center retrospective study.BMC cardiovascular disorders · 2026Article
- Eligibility and hypothetical time windows for eCPR in out-of-hospital cardiac arrest patients managed by a nationwide helicopter-emergency medical service: A multicentric, retrospective cohort study.Resuscitation plus · 2025Article
- Patient profiles and P-HEMS specific interventions performed by a HEMS team in the netherlands; A retrospective cohort study of 18,199 patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Airway management by ambulance nurses during out-of-hospital cardiac arrest.Resuscitation plus · 2025Article
- Immediate post-ECPR management strategies in the prehospital and critical care transport medicine environments.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Review
- Sub-phenotypes in patients with out-of-hospital cardiac arrest who undergo extracorporeal cardiopulmonary resuscitation: a retrospective observational study from a multicenter registry.Critical care (London, England) · 2025Observational
- Impact of prehospital extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest on survival with good neurological function: a systematic review and meta-analysis.Resuscitation plus · 2025Review
- Estimated caseload for a rotary wing prehospital extra-corporeal cardio-pulmonary resuscitation service in North West England: A retrospective eligibility study.Resuscitation plus · 2025Article
- Reply to: Comment on the use of the HOPE score in the specific case of drowning resuscitation.Resuscitation plus · 2024Article
- Successful prehospital ECMO in drowning resuscitation after prolonged submersion.Resuscitation plus · 2024Article
- ECPR-the evolving role in cardiac arrest.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
Corrections and comments
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Authors and funding
21 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe likelihood of return of spontaneous circulation with conventional advanced life support is known to have an exponential decline and therefore neurological outcome after 20 min in patients with a cardiac arrest is poor. Initiation of venoarterial ExtraCorporeal Membrane Oxygenation (ECMO) during resuscitation might improve outcomes if used in time and in a selected patient category. However, previous studies have failed to significantly reduce the time from cardiac arrest to ECMO flow to less than 60 min. We hypothesize that the initiation of Extracorporeal Cardiopulmonary Resuscitation (ECPR) by a Helicopter Emergency Medical Services System (HEMS) will reduce the low flow time and improve outcomes in refractory Out of Hospital Cardiac Arrest (OHCA) patients.
methodsThe ON-SCENE study will use a non-randomised stepped wedge design to implement ECPR in patients with witnessed OHCA between the ages of 18-50 years old, with an initial presentation of shockable rhythm or pulseless electrical activity with a high suspicion of pulmonary embolism, lasting more than 20, but less than 45 min. Patients will be treated by the ambulance crew and HEMS with prehospital ECPR capabilities and will be compared with treatment by ambulance crew and HEMS without prehospital ECPR capabilities. The primary outcome measure will be survival at hospital discharge. The secondary outcome measure will be good neurological outcome defined as a cerebral performance categories scale score of 1 or 2 at 6 and 12 months. DISCUSSION: The ON-SCENE study focuses on initiating ECPR at the scene of OHCA using HEMS. The current in-hospital ECPR for OHCA obstacles encompassing low survival rates in refractory arrests, extended low-flow durations during transportation, and the critical time sensitivity of initiating ECPR, which could potentially be addressed through the implementation of the HEMS system. When successful, implementing on-scene ECPR could significantly enhance survival rates and minimize neurological impairment.
trial registrationClinicaltyrials.gov under NCT04620070, registration date 3 November 2020.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.