ArticleNature2024
Promiscuous G-protein activation by the calcium-sensing receptor.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Atomic, structural and molecular insights into GPCR ligand binding and signalling.Nature reviews. Molecular cell biology · 2026Review
- Inhibition of Calcium-Sensing Receptor Suppresses Malignant Behaviours of Human Hepatocellular Carcinoma.Journal of cellular and molecular medicine · 2026Article
- G protein selectivity in group I metabotropic glutamate receptors.Science advances · 2026Article
- Molecular mechanism of p-Coumaric acid in the regulation of AQP2 function through the activation of calcium-sensing receptor signaling.Scientific reports · 2026Article
- LncRNA TUG1 mitigates sepsis-induced acute lung injury via a ceRNA network regulating the CALM1/PRKG1/RYR3/AQP5 axis.Scientific reports · 2026Article
- Subtype-dependent arrestin engagement of the metabotropic glutamate receptors.Nature communications · 2026Article
- Fibrosis suppressive effect and mechanism of CaSR positive allosteric modulators/p-dioxanone copolymers.Drug delivery and translational research · 2026Article
- Calcium-Sensing Receptor Regulation of Gastrointestinal Hormone Secretion.Endocrine reviews · 2026Review
- CryoEM structure of mGlu6 captures receptor activation prior to G protein coupling.Nature communications · 2026Article
- Structure of an LGR dimer, an evolutionary predecessor of glycoprotein hormone receptors.Nature communications · 2025Article
- Expanding the Reach of Membrane Protein-Ligand Interaction Studies Through the Integration of Mass Spectrometry and Membrane Mimetics.Proteomics · 2025Review
- Both calcium-sensing receptor intracellular C-terminal domains support homodimer signaling.Molecular pharmacology · 2025Article
- Calcium-sensing receptor: a potential target for liver health and diseases.Journal of translational medicine · 2025Review
- Mechanism and function of GPR3 regulated by a negative allosteric modulator.Nature communications · 2025Article
- Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3.Nature chemical biology · 2025Article
- Loss of G-protein coupled receptor 68 in hematopoietic tissues enhances long-term hematopoietic stem cell function upon aging.Stem cell research & therapy · 2025Article
- Structural insights into ligand recognition and G protein preferences across histamine receptors.Communications biology · 2025Article
- Direct effect of membrane environment on the activation of mGluR2 revealed by single-molecule FRET.Structure (London, England : 1993) · 2025Article
- A quantitative analysis of ligand binding at the protein-lipid bilayer interface.Communications chemistry · 2025Article
- Conformational diversity in class C GPCR positive allosteric modulation.Nature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 6 institutions in 2 countries.
Hao Zuo *Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, USA.ORCID 0000-0002-8812-7385
Jinseo Park *Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, USA.
Aurel FrangajDepartment of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, USA.ORCID 0000-0002-4990-513X
Jianxiang YeDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.ORCID 0009-0004-2353-2162
Guanqi LuDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Jamie J ManningDepartment of Psychiatry, Columbia University, New York, NY, USA.ORCID 0000-0002-6945-2254
Wesley B AsherDepartment of Psychiatry, Columbia University, New York, NY, USA.ORCID 0000-0001-7437-218X
Zhengyuan LuDepartment of Biological Sciences, Columbia University, New York, NY, USA.ORCID 0000-0002-4262-1193
Guo-Bin HuLaboratory for BioMolecular Structure, Brookhaven National Laboratory, Upton, NY, USA.
Liguo WangLaboratory for BioMolecular Structure, Brookhaven National Laboratory, Upton, NY, USA.
Joshua MendezNational Center for Cryo-EM Access and Training, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.ORCID 0000-0002-3317-5654
Edward EngNational Center for Cryo-EM Access and Training, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.ORCID 0000-0002-8014-7269
Zhening ZhangDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Xin LinDepartment of Psychiatry, Columbia University, New York, NY, USA.
Robert GrassucciDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Wayne A HendricksonDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0003-1412-5747
Oliver B ClarkeDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Jonathan A JavitchDepartment of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, USA. Jonathan.Javitch@nyspi.columbia.edu.ORCID 0000-0001-7395-2967
Arthur D ConigraveSchool of Life & Environmental Sciences, Charles Perkins Centre, University of Sydney, Camperdown, New South Wales, Australia. arthur.conigrave@sydney.edu.au.ORCID 0000-0002-7232-3891
Qing R FanDepartment of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, USA. qf13@cumc.columbia.edu.ORCID 0000-0002-9330-0963
Columbia University · USNew York Psychoanalytic Society and Institute · USBrookhaven National Laboratory · USNew York Structural Biology Center · USColumbia University Irving Medical Center · USThe University of Sydney · AU
Funding
NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9MStructure of the Dopamine D2-Like Receptor Binding SitesR01MH054137 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI JAVITCH, JONATHAN A · 1995 to 2025
$12.0MMolecular mechanism of dimeric G protein-coupled receptor signalingR35GM141871 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QING R FAN · 2021 to 2026
$2.7MNIGMS NIH HHS R35 GM141871NIGMS NIH HHS U24 GM129539NIMH NIH HHS R01 MH054137
Abstract
The human calcium-sensing receptor (CaSR) detects fluctuations in the extracellular Ca
Indexed as
Heterotrimeric GTP-Binding ProteinsReceptors, Calcium-SensingBinding SitesCalciumGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein alpha Subunits, GsHumansModels, MolecularProtein BindingProtein MultimerizationProtein Structure, SecondarySubstrate SpecificityCalciumCASR protein, humanGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein alpha Subunits, GsHeterotrimeric GTP-Binding ProteinsReceptors, Calcium-Sensing
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.