ArticleNature2024
Stepwise activation of a metabotropic glutamate receptor.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Crosstalk between neurotransmitters and NLRP3 inflammasome pathway: A narrative review.Molecular biology reports · 2026Review
- Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins.Nature communications · 2026Article
- Structural basis for modulation of group III mGlu receptors by transsynaptic interactions.Science advances · 2026Article
- G protein selectivity in group I metabotropic glutamate receptors.Science advances · 2026Article
- No evidence for direct physical interaction of 5-HTbioRxiv : the preprint server for biology · 2026Article
- N-Glycosylation of mGluR6 Modulates Receptor Cell-Surface Transport, G-Protein Coupling, and Interactions With Synaptic Adhesion Molecules.Journal of molecular neuroscience : MN · 2026Article
- Transmembrane Domain Dominance Drives Emergent Signaling and Allosteric Inversion in mGlubioRxiv : the preprint server for biology · 2026Article
- Subtype-dependent arrestin engagement of the metabotropic glutamate receptors.Nature communications · 2026Article
- Cryo-EM Structures of Brain-Derived G Protein-Coupled Receptors: The First Direct Visualization from Mammalian Brain Tissue.bioRxiv : the preprint server for biology · 2026Article
- Conformational dynamics of SARS-CoV-2 spike on a membrane reveals the allosteric effects of furin cleavage and the D614G mutation.Science advances · 2026Article
- CryoEM structure of mGlu6 captures receptor activation prior to G protein coupling.Nature communications · 2026Article
- Sequence constraints predispose Class D GPCRs to follow an atypical activation mechanism.bioRxiv : the preprint server for biology · 2026Article
- The Nanodisc System for Investigating Protein-Lipid Interactions.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Glutathione as a taste modulator: molecular mechanisms of interaction with umami and sweet taste receptors.Food chemistry. Molecular sciences · 2025Article
- Domain coupling in activation of a family C GPCR.Nature chemical biology · 2025Article
- Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3.Nature chemical biology · 2025Article
- Apo-state structure of the metabotropic glutamate receptor 5 transmembrane domain obtained using a photoswitchable ligand.Protein science : a publication of the Protein Society · 2025Article
- Inosine-5'-monophosphate interacts with the TAS1R3 subunit to enhance sweet taste detection.Food chemistry. Molecular sciences · 2025Article
- Triple Labeling Resolves a GPCR Intermediate State by Using Three-Color Single Molecule FRET.Journal of the American Chemical Society · 2025Article
- Conformational diversity in class C GPCR positive allosteric modulation.Nature communications · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Kaavya Krishna Kumar *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kaavyak@stanford.edu.ORCID 0000-0003-2283-4033
Haoqing Wang *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Chris HabrianDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Naomi R LatorracaDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-8310-8708
Jun XuDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-1600-583X
Evan S O'BrienDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Chensong ZhangDivision of CryoEM and Bioimaging, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
Elizabeth MontabanaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Antoine KoehlDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Susan MarquseeDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0001-7648-2163
Ehud Y IsacoffDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-4775-9359
Brian K KobilkaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kobilka@stanford.edu.ORCID 0000-0001-5958-3990
Funding
Structural Basis of Signal Instigation Through Family C GPCRsR01NS122394 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SKINIOTIS, GEORGIOS · 2021 to 2025
$3.4MG protein coupled receptor structure, dynamics, and signaling.R35NS137408 · NINDS · STANFORD UNIVERSITY · PI Brian K Kobilka · 2024 to 2026
$1.9MConformational mechanisms of mGluR gating and regulationR01NS119826 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2021 to 2024
$1.6MDecoding Structural Determinants of Efficacy and Specificity in a GPCR SubfamilyK99GM148823 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI LATORRACA, NAOMI · 2023 to 2024
$212kNIGMS NIH HHS K99 GM148823NINDS NIH HHS R01 NS119826NINDS NIH HHS R01 NS122394NINDS NIH HHS R35 NS137408
Abstract
Metabotropic glutamate receptors belong to a family of G protein-coupled receptors that are obligate dimers and possess a large extracellular ligand-binding domain that is linked via a cysteine-rich domain to their 7-transmembrane domain
Indexed as
LigandsProtein DomainsReceptor, Metabotropic Glutamate 5Allosteric RegulationFluorescenceHeterotrimeric GTP-Binding ProteinsHumansModels, MolecularProtein BindingSingle Molecule ImagingGRM5 protein, humanHeterotrimeric GTP-Binding ProteinsLigandsReceptor, Metabotropic Glutamate 5
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.