SynthesisNature human behaviour2024
Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature human behaviour, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
27.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Genome-wide meta-analyses of cross substance use disorders in diverse populations.Molecular psychiatry · 2026Pooled it
- Sex dependent genetic architecture of biochemically verified tobacco use.Psychiatry research · 2025Trial
- Exploring the Pleiotropic Genetic Architecture of Substance Use Disorders: Findings From Phenome-Wide Association Studies.Biological psychiatry global open science · 2026Review
- Convex approaches to isolate the shared and distinct genetic components of complex traits.Bioinformatics (Oxford, England) · 2026Article
- Mapping the genetic architecture of human cortical expansion and its links to neuropsychiatric disorders.bioRxiv : the preprint server for biology · 2026Article
- A decade of discovery: Leveraging genomic data in the ABCD study to illuminate adolescent neurodevelopment.Developmental cognitive neuroscience · 2026Review
- Are polygenic scores for psychiatric and substance use outcomes "ready" for clinical application? Current state and next steps.Psychiatric genetics · 2026Review
- Bidirectional genetic and phenotypic links between smoking and striatal iron content involving dopaminergic and inflammatory pathways.Addiction (Abingdon, England) · 2026Article
- Indirect Genetic Effects on Alcohol Use Disorder and Nicotine Dependence.medRxiv : the preprint server for health sciences · 2026Article
- Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestries.Nature communications · 2026Article
- Genomic insights into substance use and disinhibitory disorders.medRxiv : the preprint server for health sciences · 2026Article
- Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis.BMC medicine · 2026Article
- Genetic liability to addiction underlies comorbid bipolar and substance use disorders.medRxiv : the preprint server for health sciences · 2026Article
- Substance use disorders exhibit unique and disorder specific genetic associations with externalizing and internalizing psychopathology.medRxiv : the preprint server for health sciences · 2026Article
- Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries.Biological psychiatry · 2026Article
- Harmonizing mind acupuncture combined with nicotine replacement therapy for tobacco use disorder: a protocol for a pragmatic randomized controlled trial.Frontiers in public health · 2026Article
- Review
- Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: a multi-ancestry drug-target Mendelian randomization study.Molecular psychiatry · 2025Article
- Youth Correlates of Genetic Liability to Substance Use Disorders.medRxiv : the preprint server for health sciences · 2025Article
- Post-traumatic stress and genetic interactions affect tobacco and alcohol use after trauma: findings from a multi-ancestry cohort.Translational psychiatry · 2025Article
Corrections and comments
- Update of
Authors and funding
35 authors at 13 institutions in 3 countries.
Sylvanus Toikumo *Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-6024-0693
Mariela V Jennings *Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Benjamin K PhamDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0009-0005-5994-3593
Hyunjoon LeeDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Travis T MallardPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3265-3001
Sevim B BianchiDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
John J MeredithDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6622-6414
Laura Vilar-RibóPsychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0001-8758-523X
Heng XuDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Alexander S HatoumPsychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.
Emma C JohnsonPsychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-0394-777X
Vanessa K PazdernikDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-7566-7334
Zeal JinwalaDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0005-5062-0827
Shreya R PakalaDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Brittany S LegerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Maria NiarchouDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-8855-7393
Michael EhinmowoDepartment of Psychology, University of Ibadan, Ibadan, Nigeria.
Penn Medicine BioBank
Greg D JenkinsDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Anthony BatzlerDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Richard PendegraftDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3634-0747
Hang ZhouDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-7694-6391
Joanna M BiernackaDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-9350-4440
Brandon J CoombesDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Joel GelernterDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4067-1859
Ke XuDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Dana B HancockRTI International, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0003-2240-3604
Nancy J CoxDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Jordan W SmollerPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0381-6334
Lea K DavisDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5143-2282
Amy C JusticeVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.ORCID http://orcid.org/0000-0003-0139-5502
Henry R KranzlerMental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1018-0450
Rachel L KemberMental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8820-2659
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA. sanchezroige@ucsd.edu.ORCID http://orcid.org/0000-0001-6137-5699
University of California San Diego · USMayo Clinic in Florida · USUniversity of Pennsylvania · USVanderbilt University · USBroad Institute · USYale University · USRTI International · USWashington University in St. Louis · USMayo Clinic · USUniversitat Autònoma de Barcelona · ESUniversity of Ibadan · NGVA Connecticut Healthcare System · USVanderbilt University Medical Center · US
Funding
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JESSICA E SALVATORE · 1989 to 2026
$162.7MVanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MPhenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7MABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MAdolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5MABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7MProspective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2MABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7MBLRD VA I01 BX004820CSRD VA I01 CX001849NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR001878NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS T32 HG010464NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006378NHLBI NIH HHS U19 HL065962NIAAA NIH HHS K01 AA028292NIAAA NIH HHS K01 AA030083NIAAA NIH HHS K02 AA018755NIAAA NIH HHS P50 AA022537NIAAA NIH HHS R01 AA015416NIAAA NIH HHS U10 AA008401NICHD NIH HHS R01 HD074711NIDA NIH HHS DP1 DA054394NIDA NIH HHS K01 DA051759NIDA NIH HHS P50 DA037844NIDA NIH HHS R01 DA042090NIDA NIH HHS R01 DA050721NIDA NIH HHS R01 DA051913NIDA NIH HHS R01 DA054869NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIGMS NIH HHS P50 GM115305NIGMS NIH HHS RC2 GM092618NIGMS NIH HHS T32 GM145427NIMH NIH HHS R01 MH113362NIMH NIH HHS R01 MH121924NINDS NIH HHS R01 NS032830Tobacco-Related Disease Research Program (TRDRP) T29KT0526Tobacco-Related Disease Research Program (TRDRP) T32IR5226U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) T32HG010464U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA030083U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) 5R01DA054869U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DP1DA054394U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) K01DA051759U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) P50DA037844
Abstract
Tobacco use disorder (TUD) is the most prevalent substance use disorder in the world. Genetic factors influence smoking behaviours and although strides have been made using genome-wide association studies to identify risk variants, most variants identified have been for nicotine consumption, rather than TUD. Here we leveraged four US biobanks to perform a multi-ancestral meta-analysis of TUD (derived via electronic health records) in 653,790 individuals (495,005 European, 114,420 African American and 44,365 Latin American) and data from UK Biobank (n
Indexed as
Tobacco Use DisorderElectronic Health RecordsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleUnited States
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.