ArticleNature communications2024
Noncovalent interaction with a spirobipyridine ligand enables efficient iridium-catalyzed C-H activation.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Enhanced crystallinity of tetrahalopyridyl (THP) derivatized compounds.Chemical science · 2026Article
- Polymeric iridium catalysts for C-H borylation of arenes under batch and continuous flow conditions.Communications chemistry · 2026Article
- Transient π-coordination enables nucleophilic borylation of simple arenes.Chemical science · 2026Article
- Nanoscale supramolecular complex made of copper cyanide and a phenanthroline ligand inlaid with titanium oxide nanoparticles as effective catalysts and sensors.RSC advances · 2025Article
- Alkene Borylation-Hydrogenation Enables Highly Active, Site-Selective Cobalt-Catalyzed Borylation.Journal of the American Chemical Society · 2025Article
- Amines tuned controllable carbonylation for the synthesis of γ-lactones and 1,4-diones.Nature communications · 2025Article
- Transition-metal-free synthesis of arylboronates via thermal generation of aryl radicals from triarylbismuthines in air.Beilstein journal of organic chemistry · 2024Article
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Authors and funding
4 authors.
Funding
Abstract
Exploitation of noncovalent interactions for recognition of an organic substrate has received much attention for the design of metal catalysts in organic synthesis. The CH-π interaction is especially of interest for molecular recognition because both the C-H bonds and the π electrons are fundamental properties of organic molecules. However, because of their weak nature, these interactions have been less utilized for the control of organic reactions. We show here that the CH-π interaction can be used to kinetically accelerate catalytic C-H activation of arenes by directly recognizing the π-electrons of the arene substrates with a spirobipyridine ligand. Computation and a ligand kinetic isotope effect study provide evidence for the CH-π interaction between the ligand backbone and the arene substrate. The rational exploitation of weak noncovalent interactions between the ligand and the substrate will open new avenues for ligand design in catalysis.
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Registered trials
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