Evidence map›Paper›PMID 38632209›Full record

ArticleJournal of physiology and biochemistry2024

Ovalbumin promotes innate immune response of Caenorhabditis elegans through DAF-16 and SKN-1 pathways in insulin/IGF-1 signaling.

Haibing Pei, Zhiyin Lin, Kexin Yao, Yeqing Luo, Ping Tong, Hongbing Chen, Yong Wu, Zhihua Wu, Jinyan Gao

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of physiology and biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Haibing PeiState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, P.R. China.ORCID https://orcid.org/0009-0002-1092-3258
Zhiyin LinState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, P.R. China.ORCID https://orcid.org/0009-0009-4901-5725
Kexin YaoState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, P.R. China.ORCID https://orcid.org/0009-0003-8050-1947
Yeqing LuoState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, P.R. China.ORCID https://orcid.org/0009-0001-3636-2535
Ping TongState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, P.R. China. tongping@ncu.edu.cn.ORCID https://orcid.org/0000-0002-0298-6411
Hongbing ChenState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, P.R. China.ORCID https://orcid.org/0000-0002-4845-383X
Yong WuState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, P.R. China.ORCID https://orcid.org/0000-0001-9840-940X
Zhihua WuState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, P.R. China.ORCID https://orcid.org/0000-0001-5988-3643
Jinyan GaoCollege of Food Science & Technology, Nanchang University, Nanchang, 330047, P.R. China. gaojy2013@ncu.edu.cn.ORCID https://orcid.org/0000-0003-2180-297X
Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovalbumin (OVA) is a major allergen in eggs and could induce severe allergic reactions in sensitive individuals, where the innate immune system works as a regulator. The mechanism of how innate immunity adjusts to food allergy is relatively well-studied, however, the effects of allergen uptake on the innate immune system remain unclear. Therefore, the Caenorhabditis elegans (C. elegans) model was utilized to assess the effects of OVA on its innate immune system. OVA enhanced the immune response of C. elegans with higher survival rates under Pseudomonas aeruginosa infection. Moreover, sustaining OVA treatment improved the health states that were reflected in the prolonged lifespan, alleviated oxidative stress, accelerated growth, and promoted motility. RNA-sequencing analysis and the slow-killing assays in the mutants of insulin/IGF-1 signaling (IIS)-related genes confirmed that IIS was necessary for OVA to regulate innate immunity. Besides, OVA activated SKN-1 temporarily and facilitated the nuclear localization of DAF-16 for improving immunity and health status in C. elegans. Together, OVA could enhance the innate immune responses via DAF-16 and SKN-1 pathways in the IIS of C. elegans, and this work will provide novel insights into the regulation of innate immunity by OVA in higher organisms.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsDNA-Binding ProteinsForkhead Transcription FactorsImmunity, InnateInsulinInsulin-Like Growth Factor IOvalbuminSignal TransductionTranscription FactorsAnimalsLongevityOxidative StressPseudomonas aeruginosaPseudomonas InfectionsCaenorhabditis elegans Proteinsdaf-16 protein, C elegansDNA-Binding ProteinsForkhead Transcription FactorsInsulinInsulin-Like Growth Factor IOvalbuminskn-1 protein, C elegansTranscription FactorsCaenorhabditis elegansDAF-16Innate immunityInsulin/IGF-1 signalingOvalbuminSKN-1

Identifiers

PMID38632209
OpenAlexW4394920397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.