Evidence map›Paper›PMID 38632153›Full record

ArticleEJNMMI research2024

Mitochondrial complex I density is associated with IQ and cognition in cognitively healthy adults: an in vivo [

Ekaterina Shatalina, Thomas S Whitehurst, Ellis Chika Onwordi, Barnabas J Gilbert, Gaia Rizzo, Alex Whittington, Ayla Mansur, Hideo Tsukada, Tiago Reis Marques, Sridhar Natesan and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  2. Review
  3. Whole brain grey matter synaptic terminal density, age and intellectual functioning in schizophrenia: an in vivo [Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  4. Targeting mitophagy in neurodegenerative diseases.Nature reviews. Drug discovery · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Ekaterina ShatalinaPsychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital, Imperial College London, London, UK. katerinashatalina@gmail.com.ORCID http://orcid.org/0000-0001-8900-0792
Thomas S WhitehurstPsychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital, Imperial College London, London, UK.
Ellis Chika OnwordiPsychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital, Imperial College London, London, UK.
Barnabas J GilbertFaculty of Medicine, Imperial College London, London, UK.
Gaia RizzoInvicro, London, UK.
Alex WhittingtonInvicro, London, UK.
Ayla MansurInvicro, London, UK.
Hideo TsukadaHamamatsu Photonics K.K, Hamamatsu, Japan.
Tiago Reis MarquesInstitute of Psychiatry, Psychology and Neuroscience (IoPPN), Kings College London, London, UK.
Sridhar NatesanPsychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital, Imperial College London, London, UK.
Eugenii A RabinerInstitute of Psychiatry, Psychology and Neuroscience (IoPPN), Kings College London, London, UK.
Matthew B WallFaculty of Medicine, Imperial College London, London, UK.
Oliver D HowesPsychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital, Imperial College London, London, UK.
King's College London · GBInvicro (United Kingdom) · GBHamamatsu Photonics (Japan) · JPImperial College London · GBKing's College - North Carolina · USQueen Mary University of London · GB

Funding

Medical Research Council MC_A656_5QD30_2135Wellcome TrustWellcome Trust 094849/Z/10/Z
6 · The paper itself

Abstract

backgroundMitochondrial function plays a key role in regulating neurotransmission and may contribute to general intelligence. Mitochondrial complex I (MC-I) is the largest enzyme of the respiratory chain. Recently, it has become possible to measure MC-I distribution in vivo, using a novel positron emission tomography tracer [

resultsAnalyses were performed in a voxel-wise manner and identified significant associations between [

conclusionsTaken together, our findings support the theory that mitochondrial function may contribute to general intelligence and indicate that interindividual differences in MC-I should be a key consideration for research into mitochondrial dysfunction in conditions with cognitive impairment.

Indexed as

[18F]BCPP-EFAuditory verbal learningGeneral intelligenceIQMitochondrial complex I (MC-I)

Identifiers

PMID38632153
PMCPMC11024075
OpenAlexW4394892373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.