Evidence map›Paper›PMID 38632070›Full record

ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2024

[Therapeutic mechanism of basic fibroblast growth factor on spinal cord injury in rats based on the Notch/signal transducer and activator of transcription 3 signaling pathway].

Chunfeng Cao, Gaohai Shao, Minghua Zhang, Bo Li, Haitao Xu, Hongjun Zhang, Yiming Qu

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chunfeng CaoDepartment of Orthopedics, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, 402160, P. R. China.
Gaohai ShaoDepartment of Orthopedics, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, 402160, P. R. China.
Minghua ZhangDepartment of Orthopedics, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, 402160, P. R. China.
Bo LiDepartment of Orthopedics, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, 402160, P. R. China.
Haitao XuDepartment of Orthopedics, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, 402160, P. R. China.
Hongjun ZhangDepartment of Orthopedics, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, 402160, P. R. China.
Yiming QuDepartment of Orthopedics, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, 402160, P. R. China.
Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To explore the therapeutic effect of basic fibroblast growth factor (bFGF) on spinal cord injury (SCI) in rats and the influence of Notch/signal transducer and activator of transcription 3 (STAT3) signaling pathway. Methods: A total of 40 10-week-old male Sprague Dawley (SD) rats were selected to establish T Results: All rats survived until the experiment was completed. At immediate after modeling, the BBB scores in model group and bFGF group significantly decreased when compared to sham-operation group ( Conclusion: bFGF can improve motor function and pathological injury repair of spinal cord tissue in SCI rats, improve neuronal survival, and inhibit neuronal apoptosis, excessive activation of astrocytes in spinal cord tissue and inflammatory response, the mechanism of which may be related to the decreased activity of Notch/STAT3 signaling pathway.

Indexed as

Fibroblast Growth Factor 2Spinal Cord InjuriesAnimalsMaleRatsRats, Sprague-DawleySignal TransductionSpinal CordSTAT3 Transcription FactorTumor Necrosis Factor-alphaFibroblast Growth Factor 2STAT3 Transcription FactorTumor Necrosis Factor-alphaBasic fibroblast growth factorNotchratsignal transducer and activator of transcription 3spinal cord injury

Identifiers

PMID38632070
PMCPMC11024520
OpenAlexW4394920491

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.