Evidence map›Paper›PMID 38631601›Full record

ArticleThe Journal of steroid biochemistry and molecular biology2024

Upregulation of coagulation factor V by glucocorticoid in the preovulatory follicles of zebrafish.

Jing Huang, Chao Sun, Zhuo Huang, Yong Zhu, Shi Xi Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of steroid biochemistry and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jing HuangState Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, Fujian 361102, China.
Chao SunState Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, Fujian 361102, China.
Zhuo HuangState Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, Fujian 361102, China.
Yong ZhuState Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, Fujian 361102, China; Department of Biology, East Carolina University, 101 E. 10th Street, Greenville, NC 27858, USA.
Shi Xi ChenState Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, Fujian 361102, China; State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: chenshixi@xmu.edu.cn.
Xiamen University · CNEast Carolina University · US

Funding

"To Survive or Die" - Adamts9 in Folliculogenesis and Germ Cell LossR15HD109785 · NICHD · EAST CAROLINA UNIVERSITY · PI ZHU, YONG · 2022 to 2022
$441k
NICHD NIH HHS R15 HD109785
6 · The paper itself

Abstract

Increased cortisol levels in the preovulatory follicular fluid suggests a role of glucocorticoid in human ovulation. However, the mechanisms through which cortisol regulates the ovulatory process remain poorly understood. In this study, we examined the upregulation of f5 mRNA by glucocorticoid and its receptor (Gr) in the preovulatory follicles of zebrafish. Our findings demonstrate a significant increase in 11β-hydroxysteroid dehydrogenase type 2 (hsd11b2), a cortisol response gene, in preovulatory follicles. Additionally, hydrocortisone exerts a dose- and time-dependent upregulation of f5 mRNA in these follicles. Importantly, this stimulatory effect is Gr-dependent, as it was completely abolished in gr

Indexed as

GlucocorticoidsHydrocortisoneOvarian FollicleReceptors, GlucocorticoidUp-RegulationZebrafish11-beta-Hydroxysteroid Dehydrogenase Type 2AnimalsFemaleOvulationPromoter Regions, GeneticZebrafish Proteins11-beta-Hydroxysteroid Dehydrogenase Type 2GlucocorticoidsHydrocortisoneReceptors, GlucocorticoidZebrafish ProteinsCoagulation factorGlucocorticoidGlucocorticoid receptorOvarian follicles

Identifiers

PMID38631601
PMCPMC11140551
OpenAlexW4394852456

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.