ArticleProceedings of the National Academy of Sciences of the United States of America1985
Heat shock increases the synthesis of the poly(A)-binding protein in HeLa cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Purification and Characterization of a 70-Kilodalton Polyadenylate-Binding Protein from Pea (Pisum sativum).Plant physiology · 1992Article
- Identification and characterization of the poly(A)-binding proteins from the sea urchin: a quantitative analysis.Molecular and cellular biology · 1990Article
- Heat shock proteins are not required for the degradation of alpha-amylase mRNA and the delamellation of endoplasmic reticulum in heat-stressed barley aleurone cells.Plant physiology · 1990Article
- Association of a cellular heat shock protein with simian virus 40 large T antigen in transformed cells.Journal of virology · 1989Article
- Thermotolerance of isolated mitochondria associated with heat shock proteins.Plant physiology · 1989Article
- Distinct binding sites for zinc and double-stranded RNA in the reovirus outer capsid protein sigma 3.Molecular and cellular biology · 1988Article
- Contribution of polyadenylate sequences to the translational efficiency of globin messenger RNAs.The Biochemical journal · 1987Article
- Intracellular localization of heat shock proteins in maize.Plant physiology · 1987Article
- Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif.Nucleic acids research · 1987Article
- Increased rates of decay and reduced levels of accumulation of the major poly(A)-associated proteins of Dictyostelium during heat shock and development.Proceedings of the National Academy of Sciences of the United States of America · 1987Article
- Effect of heat shock on the metabolism of glutathione in maize roots.Plant physiology · 1986Article
- Heat shock and the heat shock proteins.The Biochemical journal · 1986Review
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Authors and funding
3 authors.
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Abstract
When HeLa cells are shifted from 37 degrees C to 45 degrees C, the synthesis of two proteins increases. Their approximate molecular masses are 73 kDa [heat shock protein 73 (hsp73)] and 87 kDa (hsp87), respectively. One of them, the hsp73, shows a specific affinity for poly(A). This protein is identical with a protein regularly found associated with translatable mRNAs in all vertebrate cells. It is well characterized by its high affinity to the poly(A) sequence of polyribosomal mRNA, and it occurs free in cytoplasm. hsp73 and the poly(A)-binding protein have the same isoelectric point and molecular size. The peptide analysis indicates that they are identical.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.