Evidence map›Paper›PMID 38631162›Full record

ReviewCell calcium2024

pH regulating mechanisms of astrocytes: A critical component in physiology and disease of the brain.

Shefeeq M Theparambil, Gulnaz Begum, Christine R Rose

Open access · hybridAbstract readReview
In one paragraph

Review in Cell calcium, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Acid-sensing ion channels as sensors of brain metabolic state.Pflugers Archiv : European journal of physiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Shefeeq M TheparambilFaculty of Health and Medicine, Department of Biomedical and Life Sciences, Lancaster University, Lancaster, LA1 4YW, Lancaster, UK. Electronic address: s.theparambil@lancaster.ac.uk.
Gulnaz BegumDepartment of Neurology, The Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA.
Christine R RoseInstitute of Neurobiology, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Heinrich Heine University Düsseldorf · DELancaster University · GBUniversity of Pittsburgh · US

Funding

Astrocytes-Mediated Regulation of Wnt/b-Catenin Pathway in Ischemic BrainR01NS110755 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BEGUM, GULNAZ · 2020 to 2024
$1.7M
Astrocytic NBCe1 in regulation of blood brain barrier integrityR21NS131754 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BEGUM, GULNAZ · 2023 to 2023
$428k
NINDS NIH HHS R01 NS110755NINDS NIH HHS R21 NS131754
6 · The paper itself

Abstract

Strict homeostatic control of pH in both intra- and extracellular compartments of the brain is fundamentally important, primarily due to the profound impact of free protons ([H

Indexed as

AstrocytesBrainAnimalsBrain DiseasesHomeostasisHumansHydrogen-Ion ConcentrationAstrocytesCarbonic anhydrasesPHSodium bicarbonate co-transporter 1 (NBCE1)Sodium proton exchanger (NHE)

Identifiers

PMID38631162
PMCPMC11423562
OpenAlexW4394580098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.