Evidence map›Paper›PMID 38630817›Full record

ArticleScience advances2024

Mitochondrial energy state controls AMPK-mediated foraging behavior in

Anežka Vodičková, Annika Müller-Eigner, Chidozie N Okoye, Andrew P Bischer, Jacob Horn, Shon A Koren, Nada Ahmed Selim, Andrew P Wojtovich

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Anežka VodičkováDepartment of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-6552-3406
Annika Müller-EignerResearch Group Epigenetics, Metabolism and Longevity, Research Institute for Farm Animal Biology (FBN), Dummerstorf 18196, Germany.
Chidozie N OkoyeDepartment of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-0037-6038
Andrew P BischerDepartment of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-3497-9291
Jacob HornDepartment of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Shon A KorenDepartment of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-3306-1999
Nada Ahmed SelimDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-9681-3457
Andrew P WojtovichDepartment of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-7725-5349
University of Rochester Medical Center · USResearch Institute for Farm Animal Biology (FBN) · DE

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Cellular and Molecular Biology at MichiganT32GM145470 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI John Chadwick Brenner · 2022 to 2026
$4.1M
Mitochondrial ROS Microdomains and Neuronal IschemiaR01NS092558 · NINDS · UNIVERSITY OF ROCHESTER · PI WOJTOVICH, ANDREW PHILLIP · 2015 to 2025
$3.7M
Mitochondrial Energy Sensing and Neuronal IschemiaR01NS115906 · NINDS · UNIVERSITY OF ROCHESTER · PI Andrew P Wojtovich · 2020 to 2026
$3.0M
NIGMS NIH HHS T32 GM145470NIH HHS P40 OD010440NINDS NIH HHS R01 NS092558NINDS NIH HHS R01 NS115906
6 · The paper itself

Abstract

Organisms surveil and respond to their environment using behaviors entrained by metabolic cues that reflect food availability. Mitochondria act as metabolic hubs and at the center of mitochondrial energy production is the protonmotive force (PMF), an electrochemical gradient generated by metabolite consumption. The PMF serves as a central integrator of mitochondrial status, but its role in governing metabolic signaling is poorly understood. We used optogenetics to dissipate the PMF in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAMP-Activated Protein KinasesAnimalsMitochondriaSignal TransductionAMP-Activated Protein KinasesCaenorhabditis elegans Proteins

Identifiers

PMID38630817
PMCPMC11023558
OpenAlexW4394903644

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.