Evidence map›Paper›PMID 38630468›Full record

ArticleACS chemical biology2024

Design, Synthesis, and Mechanistic Studies of (

Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio M Ferreira, Graham R Moran, Neil L Kelleher and 2 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Inactivation of ornithine aminotransferase by (1Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Allison N DevittDepartment of Chemistry, Chemistry of Life Processes Institute, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0003-2816-7120
Abigail L VargasDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
Wei ZhuDepartment of Chemistry, Chemistry of Life Processes Institute, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.
Benjamin James Des SoyeDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0001-5480-4192
Fatma Ayaloglu ButunDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States.
Tyler AltDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
Nicholas KaleyDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
Glaucio M FerreiraDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil.ORCID 0000-0002-1952-9428
Graham R MoranDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.ORCID 0000-0002-6807-1302
Neil L KelleherDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-8815-3372
Dali LiuDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.ORCID 0000-0002-7587-703X
Richard B SilvermanDepartment of Chemistry, Chemistry of Life Processes Institute, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0001-9034-1084
Northwestern University · USLoyola University Chicago · USUniversidade de São Paulo · BR

Funding

The UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Elena V Romanova · 2004 to 2026
$24.9M
TR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6M
New Inactivators of GABA Aminotransferase for Addiction and EpilepsyR01DA030604 · NIDA · NORTHWESTERN UNIVERSITY · PI SILVERMAN, RICHARD B · 2011 to 2020
$4.0M
Chemistry of Life Processes Predoctoral Training ProgramT32GM105538 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2013 to 2022
$2.7M
Ornithine Aminotransferase Inactivation, a New Approach for Treatment of CancersR01CA260250 · NCI · NORTHWESTERN UNIVERSITY · PI RICHARD B SILVERMAN · 2021 to 2026
$2.3M
NCI NIH HHS R01 CA260250NIDA NIH HHS P30 DA018310NIDA NIH HHS R01 DA030604NIGMS NIH HHS P41 GM108569NIGMS NIH HHS T32 GM105538
6 · The paper itself

Abstract

Human ornithine aminotransferase (

Indexed as

Drug DesignEnzyme InhibitorsOrnithine-Oxo-Acid TransaminaseCarboxylic AcidsCarcinoma, HepatocellularCrystallography, X-RayCyclohexenesHumansModels, MolecularCarboxylic AcidsCyclohexenesEnzyme InhibitorsOrnithine-Oxo-Acid Transaminase

Identifiers

PMID38630468
PMCPMC11274680
OpenAlexW4394873678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.