Evidence map›Paper›PMID 38630416›Full record

ArticleAging clinical and experimental research2024

Combining Mini-Mental State Examination and Montreal Cognitive Assessment for assessing the clinical efficacy of cholinesterase inhibitors in mild Alzheimer's disease: a pilot study.

Giovanna Furneri, Simone Varrasi, Claudia Savia Guerrera, Giuseppe Alessio Platania, Vittoria Torre, Francesco Maria Boccaccio, Maria Federica Testa, Federica Martelli, Alessandra Privitera, Grazia Razza and 6 more

Open access · hybridAbstract read
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In one paragraph

Article in Aging clinical and experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Giovanna Furneri *Department of Educational Sciences, University of Catania, Catania, Italy.ORCID http://orcid.org/0000-0002-8513-8660
Simone Varrasi *Department of Educational Sciences, University of Catania, Catania, Italy.ORCID http://orcid.org/0000-0003-1273-8419
Claudia Savia GuerreraDepartment of Educational Sciences, University of Catania, Catania, Italy.ORCID http://orcid.org/0000-0002-3744-8306
Giuseppe Alessio PlataniaDepartment of Educational Sciences, University of Catania, Catania, Italy.ORCID http://orcid.org/0000-0003-1927-6288
Vittoria TorreDepartment of Educational Sciences, University of Catania, Catania, Italy.ORCID http://orcid.org/0009-0003-2990-8733
Francesco Maria BoccaccioDepartment of Educational Sciences, University of Catania, Catania, Italy.ORCID http://orcid.org/0000-0002-9637-3156
Maria Federica TestaDepartment of Educational Sciences, University of Catania, Catania, Italy.
Federica MartelliDepartment of Educational Sciences, University of Catania, Catania, Italy.
Alessandra PriviteraDepartment of Educational Sciences, University of Catania, Catania, Italy.
Grazia RazzaDepartment of Mental Health, ASP3 Catania, Alzheimer Psychogeriatric Center, Catania, Italy.ORCID http://orcid.org/0000-0001-9896-143X
Mario SantagatiDepartment of Mental Health, ASP3 Catania, Alzheimer Psychogeriatric Center, Catania, Italy.
Santo Di NuovoDepartment of Educational Sciences, University of Catania, Catania, Italy.ORCID http://orcid.org/0000-0001-6086-7624
Concetta PirroneDepartment of Educational Sciences, University of Catania, Catania, Italy.ORCID http://orcid.org/0000-0003-1519-7988
Sabrina CastellanoDepartment of Educational Sciences, University of Catania, Catania, Italy.ORCID http://orcid.org/0009-0002-5470-142X
Filippo CaraciDepartment of Drug and Health Sciences, University of Catania, Catania, Italy. fcaraci@unict.it.ORCID http://orcid.org/0000-0002-9867-6054
Roberto MonasteroDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy. roberto.monastero@unipa.it.ORCID http://orcid.org/0000-0002-2829-523X
University of Catania · ITUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current drugs for Alzheimer's Disease (AD), such as cholinesterase inhibitors (ChEIs), exert only symptomatic activity. Different psychometric tools are needed to assess cognitive and non-cognitive dimensions during pharmacological treatment. In this pilot study, we monitored 33 mild-AD patients treated with ChEIs. Specifically, we evaluated the effects of 6 months (Group 1 = 17 patients) and 9 months (Group 2 = 16 patients) of ChEIs administration on cognition with the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), and the Frontal Assessment Battery (FAB), while depressive symptoms were measured with the Hamilton Depression Rating Scale (HDRS). After 6 months (Group 1), a significant decrease in MoCA performance was detected. After 9 months (Group 2), a significant decrease in MMSE, MoCA, and FAB performance was observed. ChEIs did not modify depressive symptoms. Overall, our data suggest MoCA is a potentially useful tool for evaluating the effectiveness of ChEIs.

Indexed as

Alzheimer DiseaseCholinesterase InhibitorsHumansMental Status and Dementia TestsPilot ProjectsTreatment OutcomeCholinesterase InhibitorsAlzheimer’s DiseaseCholinesterase inhibitorsCognitive declineMMSEMoCAPsychometric tools

Identifiers

PMID38630416
PMCPMC11023996
OpenAlexW4394872797

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.