Evidence map›Paper›PMID 38630284›Full record

ArticleArchives of toxicology2024

Characterizing the toxicological responses to inorganic arsenicals and their metabolites in immortalized human bladder epithelial cells.

Arpamas Vachiraarunwong, Min Gi, Tohru Kiyono, Shugo Suzuki, Masaki Fujioka, Guiyu Qiu, Runjie Guo, Tomoki Yamamoto, Anna Kakehashi, Masayuki Shiota and 1 more

Abstract read
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In one paragraph

Article in Archives of toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Arpamas VachiraarunwongDepartment of Environmental Risk Assessment, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.ORCID 0000-0002-0463-2289
Min GiDepartment of Environmental Risk Assessment, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan. mwei@omu.ac.jp.ORCID 0000-0003-1642-8127
Tohru KiyonoProject for Prevention of HPV-Related Cancer, Division of Collaborative Research and Development, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan.
Shugo SuzukiDepartment of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.ORCID 0000-0001-8938-9670
Masaki FujiokaDepartment of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.ORCID 0000-0003-0048-2874
Guiyu QiuDepartment of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Runjie GuoDepartment of Environmental Risk Assessment, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Tomoki YamamotoDepartment of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Anna KakehashiDepartment of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.ORCID 0000-0003-1149-1450
Masayuki ShiotaDepartment of Molecular Biology of Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Hideki WanibuchiDepartment of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan. wani@omu.ac.jp.ORCID 0000-0001-9362-4290
Osaka Metropolitan University · JPChiba Cancer Center · JPOsaka City University · JP

Funding

Japan Society for the Promotion of Science 23K09652Ministry of Health, Labour and Welfare 22KD1003Research Program for Risk Assessment Study on Food Safety JPCAFSC20212102
6 · The paper itself

Abstract

Arsenic is highly toxic to the human bladder. In the present study, we established a human bladder epithelial cell line that closely mimics normal human bladder epithelial cells by immortalizing primary uroplakin 1B-positive human bladder epithelial cells with human telomerase reverse transcriptase (HBladEC-T). The uroplakin 1B-positive human bladder epithelial cell line was then used to evaluate the toxicity of seven arsenicals (iAs

Indexed as

Activating Transcription Factor 3ArsenicalsEpithelial CellsOxidative StressReactive Oxygen SpeciesUrinary BladderApoptosisCell LineCell SurvivalHumansNF-E2-Related Factor 2Activating Transcription Factor 3ArsenicalsATF3 protein, humanNFE2L2 protein, humanNF-E2-Related Factor 2Reactive Oxygen SpeciesApoptosisArsenicalsImmortalized human bladder epithelial cellsNecroptosisToxicity

Identifiers

PMID38630284
OpenAlexW4394873142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.