Evidence map›Paper›PMID 38630262›Full record

ArticleCellular and molecular life sciences : CMLS2024

RUNX transcription factors are essential in maintaining epididymal epithelial differentiation.

Mervi Toriseva, Ida Björkgren, Arttu Junnila, Arfa Mehmood, Jesse Mattsson, Inka Raimoranta, Bongki Kim, Asta Laiho, Matthias Nees, Laura Elo and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Regulatory diversification of conservedZoological research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 5 countries.

Mervi TorisevaInstitute of Biomedicine, Cancer Research Unit and FICAN West Cancer Centre Laboratory, University of Turku and Turku University Hospital, Turku, Finland.
Ida BjörkgrenInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, University of Turku, Turku, Finland.
Arttu JunnilaInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, University of Turku, Turku, Finland.
Arfa MehmoodTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Jesse MattssonInstitute of Biomedicine, Cancer Research Unit and FICAN West Cancer Centre Laboratory, University of Turku and Turku University Hospital, Turku, Finland.
Inka RaimorantaInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, University of Turku, Turku, Finland.
Bongki KimProgram in Membrane Biology/Division of Nephrology, Massachusetts General Hospital, Simches Research Center, Boston, MA, 02114, USA.
Asta LaihoTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Matthias NeesInstitute of Biomedicine, Cancer Research Unit and FICAN West Cancer Centre Laboratory, University of Turku and Turku University Hospital, Turku, Finland.
Laura EloInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, University of Turku, Turku, Finland.
Matti PoutanenInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, University of Turku, Turku, Finland.
Sylvie BretonProgram in Membrane Biology/Division of Nephrology, Massachusetts General Hospital, Simches Research Center, Boston, MA, 02114, USA.
Petra SipiläInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, University of Turku, Turku, Finland. petra.sipila@utu.fi.ORCID http://orcid.org/0000-0001-8187-7143
University of Turku · FIÅbo Akademi University · FIKongju National University · KRMassachusetts General Hospital · US

Funding

Jalmari ja Rauha Ahokkaan Säätiö 0000-0001-8187-7143
6 · The paper itself

Abstract

Apart from the androgen receptor, transcription factors (TFs) that are required for the development and formation of the different segments of the epididymis have remained unknown. We identified TF families expressed in the developing epididymides, of which many showed segment specificity. From these TFs, down-regulation of runt related transcription factors (RUNXs) 1 and 2 expression coincides with epithelial regression in Dicer1 cKO mice. Concomitant deletion of both Runx1 and Runx2 in a mouse epididymal epithelial cell line affected cell morphology, adhesion and mobility in vitro. Furthermore, lack of functional RUNXs severely disturbed the formation of 3D epididymal organoid-like structures. Transcriptomic analysis of the epididymal cell organoid-like structures indicated that RUNX1 and RUNX2 are involved in the regulation of MAPK signaling, NOTCH pathway activity, and EMT-related gene expression. This suggests that RUNXs are master regulators of several essential signaling pathways, and necessary for the maintenance of proper differentiation of the epididymal epithelium.

Indexed as

Core Binding Factor Alpha 1 SubunitCore Binding Factor Alpha 2 SubunitAnimalsCell DifferentiationCell LineEpididymisHumansMaleMiceCore Binding Factor Alpha 1 SubunitCore Binding Factor Alpha 2 SubunitDevelopmentEpididymisEpithelial to mesenchymal transitionLoss of epithelial phenotypeMAPK signalingNOTCHRUNX1RUNX2

Identifiers

PMID38630262
PMCPMC11023966
OpenAlexW4394874305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.