Evidence map›Paper›PMID 38630048›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2024

Mechanisms of spinophilin-dependent pancreas dysregulation in obesity.

Kaitlyn C Stickel, Nikhil R Shah, Emily T Claeboe, Kara S Orr, Amber L Mosley, Emma H Doud, Teri L Belecky-Adams, Anthony J Baucum

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kaitlyn C StickelDepartment of Biology, Indiana University-Indianapolis, Indianapolis, Indiana, United States.
Nikhil R ShahMedical Neurosciences and Medical Scientist Training Program, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Emily T ClaeboeDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Kara S OrrCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana, United States.ORCID 0000-0002-1321-8581
Amber L MosleyCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Emma H DoudDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States.ORCID 0000-0003-0049-0073
Teri L Belecky-AdamsDepartment of Biology, Indiana University-Indianapolis, Indianapolis, Indiana, United States.
Anthony J BaucumDepartment of Biology, Indiana University-Indianapolis, Indianapolis, Indiana, United States.ORCID 0000-0002-4756-9865
Indiana University School of MedicineIndiana University – Purdue University Indianapolis · USUniversity of Indianapolis · US

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
Indiana Medical Scientist/Engineer Training ProgramT32GM148382 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Benjamin Gaston, Emily K Sims · 2023 to 2026
$3.9M
Spinophilin function in regulating pathological responses to psychostimulant drugR33DA041876 · NIDA · INDIANA UNIVERSITY INDIANAPOLIS · PI BAUCUM, ANTHONY J. · 2018 to 2020
$1.2M
Transforming Growth Factor Beta-Activated Kinase 1 (Tak1) in Retinal Microglial InflammationR15EY033968 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI BELECKY-ADAMS, TERI L · 2022 to 2022
$456k
Generation of cell-specific tools to determine the role of spinophilin in regulating pathological responses to psychostimulant drugs of abuseR21DA041876 · NIDA · INDIANA UNIVERSITY INDIANAPOLIS · PI BAUCUM, ANTHONY J. · 2016 to 2017
$364k
HHS | NIH | National Cancer Institute (NCI) P30CA082709HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR002529HHS | NIH | National Eye Institute (NEI) R15EY033968HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P30DK097512HHS | NIH | NIDA | National Drug Abuse Treatment Clinical Trials Network (CTN) R21/R33DA041876NCATS NIH HHS UL1 TR002529NCI NIH HHS P30 CA082709NEI NIH HHS R15 EY033968NIDA NIH HHS R33 DA041876NIDDK NIH HHS P30 DK097512
6 · The paper itself

Abstract

Spinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting protein that acts as a scaffold of PP1 to its substrates. Spinophilin knockout (

Indexed as

Microfilament ProteinsObesityPancreasAnimalsDiabetes MellitusFemaleGene Knockout TechniquesInsulin-Secreting CellsMaleMiceNeurabinsPancreatic DiseasesWeight GainMicrofilament ProteinsNeurabinsdiabesityobesityprotein phosphatase 1scaffolding proteinstype 2 diabetes

Identifiers

PMID38630048
PMCPMC11427100
OpenAlexW4394873887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.