Evidence map›Paper›PMID 38629858›Full record

ArticleAntimicrobial agents and chemotherapy2024

Inactivation of the ribosome assembly factor RimP causes streptomycin resistance and impairs motility in

Zhihui Lyu, Yunyi Ling, Ambro van Hoof, Jiqiang Ling

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Distinctive Lacritin Cleavage-Potentiated Bactericidal Alteration of thebioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zhihui LyuDepartment of Cell Biology and Molecular Genetics, The University of Maryland, College Park, Maryland, USA.ORCID 0009-0006-8781-5983
Yunyi LingDepartment of Cell Biology and Molecular Genetics, The University of Maryland, College Park, Maryland, USA.
Ambro van HoofDepartment of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0002-7800-9764
Jiqiang LingDepartment of Cell Biology and Molecular Genetics, The University of Maryland, College Park, Maryland, USA.ORCID 0000-0003-4466-8304
University of Maryland, College Park · USThe University of Texas Health Science Center at Houston · US

Funding

RNAse functions in post-transcriptional gene regulationR35GM141710 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VAN HOOF, AMBRO · 2021 to 2025
$2.4M
Regulation and Physiological Roles of Translational FidelityR35GM136213 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI LING, JIQIANG · 2020 to 2024
$2.0M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM136213HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM141710NIGMS NIH HHS R35 GM136213NIGMS NIH HHS R35 GM141710
6 · The paper itself

Abstract

The ribosome is the central hub for protein synthesis and the target of many antibiotics. Although the majority of ribosome-targeting antibiotics inhibit protein synthesis and are bacteriostatic, aminoglycosides promote protein mistranslation and are bactericidal. Understanding the resistance mechanisms of bacteria against aminoglycosides is not only vital for improving the efficacy of this critically important group of antibiotics but also crucial for studying the molecular basis of translational fidelity. In this work, we analyzed

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialMicrobial Sensitivity TestsStreptomycinBacterial ProteinsProtein BiosynthesisRibosomal ProteinsRibosomesSalmonellaSalmonella typhimuriumAnti-Bacterial AgentsBacterial ProteinsRibosomal ProteinsStreptomycinantibiotic failurepathogenribosomal fidelity

Identifiers

PMID38629858
PMCPMC11620500
OpenAlexW4394873284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.