ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Secondary Structure in Enzyme-Inspired Polymer Catalysts Impacts Water Oxidation Efficiency.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Genetic Surfaceome E. coli Reprogramming Enables Selective Water Oxidation.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Bioelectrochemical Systems: Prioritizing Energy Density, Long-Term Stability, and Validation.ACS energy letters · 2025Review
- Enhancing the Stability and Anticancer Activity ofPolymers · 2024Article
- Secondary Structure in Enzyme-Inspired Polymer Catalysts Impacts Water Oxidation Efficiency.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
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Authors and funding
5 authors.
Funding
Abstract
Protein structure plays an essential role on their stability, functionality, and catalytic activity. In this work, the interplay between the β-sheet structure and its catalytic implications to the design of enzyme-inspired materials is investigated. Here, inspiration is drawn from the active sites and β-sheet rich structure of the highly efficient multicopper oxidase (MCO) to engineer a bio-inspired electrocatalyst for water oxidation utilizing the abundant metal, copper. Copper ions are coordinated to poly-histidine (polyCuHis), as they are in MCO active sites. The resultant polyCuHis material effectively promotes water oxidation with low overpotentials (0.15 V) in alkaline systems. This activity is due to the 3D structure of the poly-histidine backbone. By increasing the prevalence of β-sheet structure and decreasing the random coil nature of the polyCuHis secondary structures, this study is able to modulates the electrocatalytic activity of this material is modulated, shifting it toward water oxidation. These results highlight the crucial role of the local environment at catalytic sites for efficient, energy-relevant transformations. Moreover, this work highlights the importance of conformational structure in the design of scaffolds for high-performance electrocatalysts.
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