Evidence map›Paper›PMID 38629583›Full record

ArticleAmerican journal of epidemiology2024

Indicators of cure for women living after uterine and ovarian cancers: a population-based study.

Fabiola Giudici, Angela De Paoli, Federica Toffolutti, Stefano Guzzinati, Silvia Francisci, Lauro Bucchi, Gemma Gatta, Elena Demuru, Sandra Mallone, Antonella Dal Cin and 33 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 20 institutions in 6 countries.

Fabiola GiudiciCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.ORCID 0000-0002-4160-3479
Angela De PaoliEpidemiological Department, Azienda Zero, 35132 Padua, Italy.ORCID 0000-0001-9864-6325
Federica ToffoluttiCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.ORCID 0000-0002-2907-0745
Stefano GuzzinatiEpidemiological Department, Azienda Zero, 35132 Padua, Italy.ORCID 0000-0002-4908-5506
Silvia FrancisciNational Centre for Disease Prevention and Health Promotion, National Institute of Health, 00161 Rome, Italy.ORCID 0000-0002-1552-1744
Lauro BucchiEmilia-Romagna Cancer Registry, Romagna Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, 47121 Forlì, Italy.ORCID 0000-0002-6771-8119
Gemma GattaEvaluative Epidemiology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milano, Italy.ORCID 0000-0003-4160-6458
Elena DemuruDepartment of Oncology and Molecular Medicine, National Institute of Health, 00161 Rome, Italy.ORCID 0000-0003-2979-4169
Sandra MalloneNational Centre for Disease Prevention and Health Promotion, National Institute of Health, 00161 Rome, Italy.ORCID 0000-0001-6686-6905
Antonella Dal CinEpidemiological Department, Azienda Zero, 35132 Padua, Italy.
Adele CaldarellaTuscany Cancer Registry, Institute for cancer research, prevention and clinical network, 50139 Florence, Italy.ORCID 0000-0003-3439-2295
Francesco CuccaroLocal Health Unit of Barletta-Andria-Trani, Section of the Cancer Registry of Puglia, 76121 Barletta, Italy.ORCID 0000-0002-7012-2885
Enrica MigliorePiedmont Cancer Registry, Centro di Riferimento per l'Epidemiologia e la Prevenzione Oncologica (CPO) Piemonte and University of Turin, 10123 Turin, Italy.ORCID 0000-0003-0121-6295
Maria Letizia GambinoRegistro tumori ATS Insubria (Provincia di Como e Varese), S.S. Epidemiologia Registri Specializzati e Reti di Patologia, 21100 Varese, Italy.
Alessandra RavaioliEmilia-Romagna Cancer Registry, Romagna Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, 47121 Forlì, Italy.ORCID 0000-0002-8778-6397
Antonella PuppoLiguria Cancer Registry, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.
Margherita FerranteRegistro tumori integrato di Catania-Messina-Enna, Igiene Ospedaliera, Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco, 95123 Catania, Italy.ORCID 0000-0001-7596-2464
Giuliano CarrozziEmilia-Romagna Cancer Registry, Modena Unit, Public Health Department, Local Health Authority, 41126 Modena, Italy.
Fabrizio StracciUmbria Cancer Registry, Public Health Section, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0002-7594-6680
Antonino MusolinoEmilia-Romagna Cancer Registry, Parma Unit, Medical Oncology Unit, University Hospital of Parma, 43126 Parma, Italy.ORCID 0000-0002-7979-6261
Cinzia GasparottiRegistro tumori ATS Brescia, Struttura Semplice Epidemiologia, ATS Brescia, 25124 Brescia, Italy.
Rossella CavalloCancer Registry Azienda Sanitaria Locale (ASL) Salerno, Dipartimento di Prevenzione, 84124 Salerno, Italy.ORCID 0009-0003-4830-621X
Walter MazzuccoClinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico (AOUP) di Palermo, 90127 Palermo, Italy.ORCID 0000-0001-5090-1366
Maria Francesca VitaleRegistro Tumori ASL Napoli 3 Sud, 80031 Napoli, Italy.
Giuseppe CasconeAzienda Sanitaria Provinciale (ASP) Ragusa, Dipartimento di Prevenzione, Registro Tumori, 97100 Ragusa, Italy.ORCID 0009-0001-8699-2586
Paola BallotariOsservatorio Epidemiologico, ATS Val Padana, 46100 Mantova, Italy.ORCID 0000-0003-4057-3535
Stefano FerrettiEmilia-Romagna Cancer Registry, Ferrara Unit, Local Health Authority, Ferrara, and University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-5241-2101
Lucia MangoneEmilia-Romagna Cancer Registry, Reggio Emilia Unit, Epidemiology Unit, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.ORCID 0000-0002-5089-5178
Roberto Vito RizzelloTrento Province Cancer Registry, Unit of Clinical Epidemiology, 38123 Trento, Italy.ORCID 0009-0006-6452-5529
Giuseppe SampietroBergamo Cancer Registry, Epidemiological Service, Agenzia di Tutela della Salute, 24121 Bergamo, Italy.ORCID 0000-0001-8173-7810
Michael MianInnovation, Research and Teaching Service (SABES-ASDAA), Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, 39100 Bolzano-Bozen, Italy.ORCID 0000-0003-2539-5996
Lorenza BoschettiCancer Registry of the Province of Pavia, 27200 Pavia, Italy.ORCID 0009-0000-1645-2587
Rocco GalassoUnit of Regional Cancer Registry, Clinical Epidemiology and Biostatistics, IRCCS Centro di Riferimento Oncologico di Basilicata (CROB), 85028 Rionero in Vulture, Italy.ORCID 0000-0003-4831-6437
Francesca BellaSiracusa Cancer Registry, Provincial Health Authority of Siracusa, 96100 Siracusa, Italy.
Daniela PirasNord Sardegna Cancer Registry, ASL, 07100 Sassari, Italy.ORCID 0009-0002-2606-7716
Alessandra SessaMonitoraggio rischio ambientale e Registro Tumori ASL Caserta, 81100 Caserta, Italy.
Pietro SeghiniEmilia-Romagna Cancer Registry, Piacenza Unit, Public Health Department, AUSL Piacenza, 29100 Piacenza, Italy.ORCID 0000-0002-4311-0213
Anna Clara FanettiSondrio Cancer Registry, Agenzia di Tutela della Salute della Montagna, 23100 Sondrio, Italy.
Pasquala PinnaNuoro Cancer Registry, RT Nuoro, Servizio Igiene e Sanità Pubblica, ASL Nuoro, 08100 Nuoro, Italy.
Roberta De AngelisDepartment of Oncology and Molecular Medicine, National Institute of Health, 00161 Rome, Italy.ORCID 0000-0001-7787-3043
Diego SerrainoCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.ORCID 0000-0003-0565-8920
Luigino Dal MasoCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.ORCID 0000-0001-6163-200X
AIRTUM working group
Centro di Riferimento Oncologico · ITIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITNational Centre for Disease Prevention and Control · ITNational Institute of Health · AMPublic Health Department · INAgenzia Regionale Sanitaria della Puglia · ITASL Roma · ITAssociazione Istituzione Libera Università Nuorese · ITAzienda Ospedaliera di Valtellina e Valchiavenna · ITAzienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo · ITAzienda Sanitaria Unità Locale di Reggio Emilia · ITBrescia University · USCentro di Riferimento Oncologico della Basilicata · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITHealth Protection Agency · MVNational Cancer Registry · IEOspedale Policlinico San Martino · ITPiedmont Reference Center for Epidemiology and Cancer Prevention · ITPoliclinico Universitario di Catania · ITUniversity of Ferrara · IT

Funding

Italian Association for Cancer Research 28893
6 · The paper itself

Abstract

This study aims to estimate long-term survival, cancer prevalence, and several cure indicators for Italian women with gynecological cancers. Thirty-one cancer registries, representing 47% of the Italian female population, were included. Mixture cure models were used to estimate net survival, cure fraction, time to cure (when 5-year conditional net survival becomes > 95%), cure prevalence (women who will not die of cancer), and already cured (living longer than time to cure). In 2018, 0.4% (121 704) of Italian women were alive after diagnosis of corpus uteri cancer, 0.2% (52 551) after cervical cancer, and 0.2% (52 153) after ovarian cancer. More than 90% of patients with uterine cancers and 83% with ovarian cancer will not die from their neoplasm (cure prevalence). Women with gynecological cancers have a residual excess risk of death <5% at 5 years after diagnosis. The cure fraction was 69% for corpus uteri, 32% for ovarian, and 58% for cervical cancer patients. Time to cure was ≤10 years for women with gynecological cancers aged <55 years; 74% of patients with cervical cancer, 63% with corpus uteri cancer, and 55% with ovarian cancer were already cured. These results can contribute to improving follow-up programs for women with gynecological cancers and supporting efforts against discrimination of already cured ones. This article is part of a Special Collection on Gynecological Cancers.

Indexed as

Ovarian NeoplasmsRegistriesUterine NeoplasmsAdultAgedAged, 80 and overCancer SurvivorsFemaleHumansItalyMiddle AgedPrevalenceUterine Cervical Neoplasmscancer prevalencecervical cancercorpus uteri cancercure fractionlong-term survivalmixture cure modelsovarian cancertime to cure

Identifiers

PMID38629583
PMCPMC11369216
OpenAlexW4394869040

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.