Evidence map›Paper›PMID 38629495›Full record

ReviewNatural product reports2024

Verticillins: fungal epipolythiodioxopiperazine alkaloids with chemotherapeutic potential.

Herma C Pierre, Chiraz Soumia M Amrine, Michael G Doyle, Amrita Salvi, Huzefa A Raja, Jonathan R Chekan, Andrew C Huntsman, James R Fuchs, Kebin Liu, Joanna E Burdette and 2 more

Open access · hybridAbstract readReview
In one paragraph

Review in Natural product reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Isolation and characterization ofFrontiers in microbiology · 2026
    Article
  2. Total Synthesis and Anticancer Study of (+)-Verticillin A.Journal of the American Chemical Society · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Herma C PierreDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, North Carolina 27402, USA. nicholas_oberlies@uncg.edu.
Chiraz Soumia M AmrineDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, North Carolina 27402, USA. nicholas_oberlies@uncg.edu.
Michael G DoyleDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, North Carolina 27402, USA. nicholas_oberlies@uncg.edu.
Amrita SalviDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, 900 S. Ashland Ave (M/C 870), Chicago, Illinois 60607, USA.
Huzefa A RajaDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, North Carolina 27402, USA. nicholas_oberlies@uncg.edu.ORCID 0000-0002-0824-9463
Jonathan R ChekanDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, North Carolina 27402, USA. nicholas_oberlies@uncg.edu.ORCID 0000-0003-4651-0594
Andrew C HuntsmanDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, 500 W. 12th Ave., Columbus, Ohio 43210, USA.
James R FuchsDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, 500 W. 12th Ave., Columbus, Ohio 43210, USA.ORCID 0000-0002-8743-6389
Kebin LiuDepartment of Biochemistry and Molecular Biology and the Georgia Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA.ORCID 0000-0003-1965-7240
Joanna E BurdetteDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, 900 S. Ashland Ave (M/C 870), Chicago, Illinois 60607, USA.ORCID 0000-0002-7271-6847
Cedric J PearceMycosynthetix, Inc., Hillsborough, NC, 27278, USA.
Nicholas H OberliesDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, North Carolina 27402, USA. nicholas_oberlies@uncg.edu.ORCID 0000-0002-0354-8464
University of North Carolina at Greensboro · USThe Ohio State University · USUniversity of Illinois Chicago · USAugusta University · USMycosynthetix (United States) · US

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JIMMY ORJALA · 2007 to 2026
$27.2M
Predoctoral Training: Innovative Technologies for Natural Products and Integrative Medicine ResearchT32AT008938 · NCCIH · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI Nadja B Cech, Jonathan Rodi Chekan · 2016 to 2026
$1.6M
NCCIH NIH HHS T32 AT008938NCI NIH HHS P01 CA125066
6 · The paper itself

Abstract

Covering: 1970 through June of 2023Verticillins are epipolythiodioxopiperazine (ETP) alkaloids, many of which possess potent, nanomolar-level cytotoxicity against a variety of cancer cell lines. Over the last decade, their

Indexed as

AlkaloidsAntineoplastic AgentsFungiHumansIndolesMolecular StructureMultigene FamilyPiperazinesAlkaloidsAntineoplastic AgentsIndolesPiperazinesverticillins

Identifiers

PMID38629495
PMCPMC11409914
OpenAlexW4394873162

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.