Evidence map›Paper›PMID 38629375›Full record

ArticleAnti-cancer agents in medicinal chemistry2024

The Development of Organotin(IV) N-Ethyl-N-Benzyldithiocarbamate Complexes: A Study on Their Synthesis, Characterization, and Cytocidal Effects on A549 Cell Line.

Nurul Amalina Abd Aziz, Normah Awang, Nurul Farahana Kamaludin, Nur Najmi Mohamad Anuar, Asmah Hamid, Kok Meng Chan, Suhana Arshad

Abstract read
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In one paragraph

Article in Anti-cancer agents in medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Mitochondrial apoptosis and GScientific reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Nurul Amalina Abd AzizCenter for Toxicology and Health Risk Studies, Faculty of Health Sciences, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.ORCID 0009-0004-9946-7395
Normah AwangCenter for Toxicology and Health Risk Studies, Faculty of Health Sciences, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.ORCID 0000-0002-3772-2088
Nurul Farahana KamaludinCenter for Toxicology and Health Risk Studies, Faculty of Health Sciences, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.ORCID 0000-0002-2202-5917
Nur Najmi Mohamad AnuarCenter for Toxicology and Health Risk Studies, Faculty of Health Sciences, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.ORCID 0000-0001-6257-8316
Asmah HamidCenter for Toxicology and Health Risk Studies, Faculty of Health Sciences, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.ORCID 0000-0002-9657-9453
Kok Meng ChanProduct Stewardship and Toxicology, Petroliam Nasional Berhad, Level 13, Tower 1, PETRONAS Twin Towers, KLCC, 50088 Kuala Lumpur, Malaysia.ORCID 0000-0001-8837-125X
Suhana ArshadX-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia.ORCID 0000-0002-0977-8957
National University of Malaysia · MYPetronas (Malaysia) · MYUniversiti Sains Malaysia · MY

Funding

Ministry of Higher Education (MOHE), Malaysia through the Fundamental Research Grant Scheme (FRGS) FRGS/1/2021/STG04/UKM/02/5
6 · The paper itself

Abstract

backgroundOrganotin(IV) complexes of dithiocarbamate are vital in medicinal chemistry, exhibiting potential in targeting cancer cells due to their unique properties that enhance targeted delivery. This study aimed to synthesize and characterize organotin(IV)

methodsThe two ONBDC derivatives - ONBDC 1 (dimethyltin(IV)

resultsBoth compounds were synthesized and characterized successfully via elemental and spectroscopies analysis. MTT assay revealed that ONBDC 2 demonstrated remarkable cytotoxicity towards A549 cells, with an IC

conclusionThus, it was shown that ONBDC 2 could have important anticancer properties and should be further explored as a top contender for creating improved and specialized cancer treatments.

Indexed as

Antineoplastic AgentsCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorOrganotin CompoundsA549 CellsCell SurvivalDrug DevelopmentHumansMolecular StructureStructure-Activity RelationshipThiocarbamatesAntineoplastic AgentsOrganotin CompoundsThiocarbamatesA549 cells.cytotoxicitydithiocarbamateelementalOrganotin(IV)spectroscopysynthesis

Identifiers

PMID38629375
OpenAlexW4394874102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.