Evidence map›Paper›PMID 38629290›Full record

ArticleHypertension (Dallas, Tex. : 1979)2024

Genetic Deletion of β-Arrestin 2 From the Subfornical Organ and Other Periventricular Nuclei in the Brain Alters Fluid Homeostasis and Blood Pressure.

Natalia M Mathieu, Eden E Tan, John J Reho, Daniel T Brozoski, Patricia C Muskus, Ko-Ting Lu, Kelsey K Wackman, Justin L Grobe, Pablo Nakagawa, Curt D Sigmund

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. β-Arrestin-2 Regulates Sodium Taste Processing.Hypertension (Dallas, Tex. : 1979) · 2026
    Article
  2. Article
  3. The brain and hypertension: how the brain regulates and suffers from blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Natalia M MathieuDepartment of Physiology (N.M.M., J.J.R., D.T.B., P.C.M., K.-T.L., K.K.W., J.L.G., P.N., C.D.S.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0003-4414-8798
Eden E TanSUPREMES Program, Marquette University and Medical College of Wisconsin, Milwaukee (E.E.T.).
John J RehoDepartment of Physiology (N.M.M., J.J.R., D.T.B., P.C.M., K.-T.L., K.K.W., J.L.G., P.N., C.D.S.), Medical College of Wisconsin, Milwaukee.
Daniel T BrozoskiDepartment of Physiology (N.M.M., J.J.R., D.T.B., P.C.M., K.-T.L., K.K.W., J.L.G., P.N., C.D.S.), Medical College of Wisconsin, Milwaukee.
Patricia C MuskusDepartment of Physiology (N.M.M., J.J.R., D.T.B., P.C.M., K.-T.L., K.K.W., J.L.G., P.N., C.D.S.), Medical College of Wisconsin, Milwaukee.
Ko-Ting LuDepartment of Physiology (N.M.M., J.J.R., D.T.B., P.C.M., K.-T.L., K.K.W., J.L.G., P.N., C.D.S.), Medical College of Wisconsin, Milwaukee.
Kelsey K WackmanDepartment of Physiology (N.M.M., J.J.R., D.T.B., P.C.M., K.-T.L., K.K.W., J.L.G., P.N., C.D.S.), Medical College of Wisconsin, Milwaukee.
Justin L GrobeDepartment of Physiology (N.M.M., J.J.R., D.T.B., P.C.M., K.-T.L., K.K.W., J.L.G., P.N., C.D.S.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0001-9737-0873
Pablo NakagawaDepartment of Physiology (N.M.M., J.J.R., D.T.B., P.C.M., K.-T.L., K.K.W., J.L.G., P.N., C.D.S.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0002-1887-7367
Curt D SigmundDepartment of Physiology (N.M.M., J.J.R., D.T.B., P.C.M., K.-T.L., K.K.W., J.L.G., P.N., C.D.S.), Medical College of Wisconsin, Milwaukee.
Medical College of Wisconsin · USMarquette University · US

Funding

Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2M
PPARG-dependent Mechanisms Control Endothelial-Smooth Muscle Coordination, Arterial Pressure, Vasomotor Function and Arterial StiffnessR35HL144807 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI SIGMUND, CURT DANIEL · 2019 to 2024
$5.5M
Interaction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4M
Impact of Early Life Sodium Intake on Growth and Metabolism – Role of Hypothalamic MechanismsR01DK133121 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI GROBE, JUSTIN L, SEGAR, JEFFREY L · 2022 to 2025
$1.9M
Role of the prorenin receptor in blood pressure and autonomic control through the local activation of the renin angiotensin system in the brainstemK01HL153101 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI NAKAGAWA, PABLO · 2020 to 2024
$562k
American Heart Association-American Stroke Association 23CDA1048244NHLBI NIH HHS K01 HL153101NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL134850NHLBI NIH HHS R35 HL144807NIDDK NIH HHS R01 DK133121
6 · The paper itself

Abstract

backgroundANG (angiotensin II) elicits dipsogenic and pressor responses via activation of the canonical Gαq (G-protein component of the AT

methodsMale and female

results

conclusionsOverall, these data indicate that ARRB2 in selective cardiovascular nuclei in the brain, including the subfornical organ, counterbalances canonical AT

Indexed as

beta-Arrestin 2Blood PressureHomeostasisSubfornical OrganAngiotensin IIAnimalsBrainFemaleMaleMiceMice, KnockoutReceptor, Angiotensin, Type 1Angiotensin IIArrb2 protein, mousebeta-Arrestin 2Receptor, Angiotensin, Type 1arrestinblood pressurehypertensionreceptors, G-protein coupledsubfornical organ

Identifiers

PMID38629290
PMCPMC11096025
OpenAlexW4394873403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.