Evidence map›Paper›PMID 38629274›Full record

ArticleCirculation research2024

Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation.

Wenqi Ma, Kangni Jia, Haomai Cheng, Hong Xu, Zhigang Li, Hang Zhang, Hongyang Xie, Hang Sun, Lei Yi, Zhiyong Chen and 7 more

Abstract read
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Article in Circulation research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
21.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 81 citations in OpenAlex.

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  18. Glycolysis enzymes and cellular lactylation in tumour.Clinical and translational medicine · 2026
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Wenqi Ma *Department of Cardiovascular Medicine, Ruijin Hospital (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong University School of Medicine, China.
Kangni Jia *Department of Cardiovascular Medicine, Ruijin Hospital (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0000-0003-4797-7671
Haomai Cheng *Department of Cardiovascular Medicine, Ruijin Hospital (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0009-0002-4898-4363
Hong XuDepartment of Cardiovascular Medicine, Ruijin Hospital (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0000-0001-8883-519X
Zhigang LiDepartment of Cardiovascular Medicine, Ruijin Hospital (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong University School of Medicine, China.
Hang ZhangDepartment of Cardiovascular Medicine, Ruijin Hospital (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong University School of Medicine, China.
Hongyang XieInstitute of Cardiovascular Diseases (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0000-0003-1622-9304
Hang SunDepartment of Cardiovascular Medicine, Ruijin Hospital (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0009-0006-7422-9272
Lei YiDepartment of Cardiovascular Medicine, Ruijin Hospital (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0000-0001-6388-0074
Zhiyong ChenDepartment of Cardiovascular Medicine, Ruijin Hospital (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong University School of Medicine, China.
Shengzhong DuanDepartment of Cardiovascular Medicine, Ruijin Hospital (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong University School of Medicine, China.
Motoaki SanoDepartment of Cardiology, Keio University School of Medicine, Tokyo, Japan (M.S., K.F.).ORCID 0000-0003-1771-8310
Keiichi FukudaDepartment of Cardiology, Keio University School of Medicine, Tokyo, Japan (M.S., K.F.).ORCID 0000-0003-1413-0482
Lin LuDepartment of Cardiovascular Medicine, Ruijin Hospital (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0000-0003-0145-8008
Fei GaoBeijing Anzhen Hospital, Capital Medical University, China (F.G.).ORCID 0000-0003-3633-3133
Ruiyan ZhangDepartment of Cardiovascular Medicine, Ruijin Hospital (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0000-0003-4131-8544
Xiaoxiang YanDepartment of Cardiovascular Medicine, Ruijin Hospital (W.M., K.J., H.C., Z.L., H.Z., H.X., L.Z., Z.W., Y.C., H.S., L.Y., Z.C., L.L., R.Z., X.Y.), Shanghai Jiao Tong University School of Medicine, China.ORCID 0000-0003-3046-9902
Ruijin Hospital · CNZTE (United States) · USKeio University · JPBeijing Anzhen Hospital · CNShanghai Ninth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMedial arterial calcification is a chronic systemic vascular disorder distinct from atherosclerosis and is commonly observed in patients with chronic kidney disease, diabetes, and aging individuals. We previously showed that NR4A3 (nuclear receptor subfamily 4 group A member 3), an orphan nuclear receptor, is a key regulator in apo (apolipoprotein) A-IV-induced atherosclerosis progression; however, its role in vascular calcification is poorly understood.

methodsWe generated NR4A3

resultsNR4A3 expression was upregulated in calcified aortic tissues from chronic kidney disease mice, 1,25(OH)

conclusionsTaken together, our findings reveal that NR4A3-mediated histone lactylation is a novel metabolome-epigenome signaling cascade mechanism that participates in the pathogenesis of medial arterial calcification.

Indexed as

HistonesMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularNuclear Receptor Subfamily 4, Group A, Member 3Vascular CalcificationAnimalsCells, CulturedDNA-Binding ProteinsHumansMaleMiceMyocytes, Smooth MuscleNerve Tissue ProteinsReceptors, SteroidReceptors, Thyroid HormoneDNA-Binding ProteinsHistonesNerve Tissue ProteinsNR4A3 protein, humanNr4a3 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 3Receptors, SteroidReceptors, Thyroid Hormoneepigeneticsglycolysishistonesnuclear receptor NR4A3vascular calcification

Identifiers

PMID38629274
OpenAlexW4394874247

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.