Evidence map›Paper›PMID 38629074›Full record

ArticleFrontiers in immunology2024

Donor

Johannes Schetelig, Henning Baldauf, Falk Heidenreich, Jorinde D Hoogenboom, Stephen R Spellman, Alexander Kulagin, Thomas Schroeder, Henrik Sengeloev, Peter Dreger, Edouard Forcade and 19 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Novel conditioning and prophylaxis regimens for relapse prevention.Hematology. American Society of Hematology. Education Program · 2024
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 11 countries.

Johannes ScheteligDepartment of Internal Medicine I, University Hospital TU Dresden, Dresden, Germany.
Henning BaldaufClinical Trials Unit, DKMS Group, Dresden, Germany.
Falk HeidenreichDepartment of Internal Medicine I, University Hospital TU Dresden, Dresden, Germany.
Jorinde D HoogenboomEBMT Leiden Study Unit, Leiden, Netherlands.
Stephen R SpellmanCenter for International Blood and Marrow Transplant Research, National Marrow Donor Program (NMDP), Minneapolis, MN, United States.
Alexander KulaginRM Gorbacheva Research Institute, Pavlov University, St. Petersburg, Russia.
Thomas SchroederKlinik für Hämatologie und Stammzelltransplantation, Universitätsklinikum Essen, Essen, Germany.
Henrik SengeloevBone Marrow Transplant Unit, Department of Hematology, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.
Peter DregerDepartment of Medicine V, University of Heidelberg, Heidelberg, Germany.
Edouard ForcadeService Hématologie clinique de Thérapie cellulaire, Centre Hospitalier Universitaire Bordeaux, Université de Bordeaus, Bordeaux, France.
Jan VydraTransplant Unit and Intensive Care Unit, Institute of Hematology and Bood Transfusion, Prague, Czechia.
Eva Maria Wagner-DrouetCenter for Cellular Immunotherapy and Stem Cell Transplantation, Third Medical Department, Hematology and Oncology, University Cancer Center Mainz, Mainz, Germany.
Goda ChoiUniversity Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Shankara PaneeshaDepartment of Haematology & Stem Cell Transplantation, Birmingham Heartlands Hospital, Birmingham, United Kingdom.
Nuno A A MirandaDepartment of Hematology, Instituto Português de Oncologia de Lisboa, Lisboa, Portugal.
Alina TanaseDepartment of Stem Cell Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
Liesbeth C de WreedeBiomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands.
Vinzenz LangeDKMS Life Science Lab, Dresden, Germany.
Alexander H SchmidtDKMS Life Science Lab, Dresden, Germany.
Jürgen SauterDKMS Group, Tübingen, Germany.
Joshua A FeinDepartment of Hematology & Medical Oncology, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY, United States.
Yung-Tsi BolonCenter for International Blood and Marrow Transplant Research, National Marrow Donor Program (NMDP), Minneapolis, MN, United States.
Meilun HeCenter for International Blood and Marrow Transplant Research, National Marrow Donor Program (NMDP), Minneapolis, MN, United States.
Steven G E MarshAnthony Nolan Research Institute, Royal Free Hospital, London & Cancer Institute, University College London, London, United Kingdom.
Shahinaz M GadallaNational Cancer Institute, Division of Cancer Epidemiology & Genetics, Bethesda, MD, United States.
Sophie PaczesnyDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, United States.
Annalisa RuggeriHaematology and BMT, Ospedale San Raffaele s.r.l., Milan, Italy.
Christian ChabannonInstitut Paoli-Calmettes, Centre de Lutte Contre le Cancer, Marseille, France.
Katharina FleischhauerInstitute for Experimental Cellular Therapy, University Hospital, Essen, Germany.
Deutsche Knochenmarkspenderdatei · DENational Marrow Donor Program · USEssen University Hospital · DECentre Hospitalier Universitaire de Bordeaux · FRCopenhagen University Hospital · DKEuropean Society for Blood and Marrow Transplantation · NLFirst Pavlov State Medical University of St. Petersburg · RUHeartlands Hospital · GBHeidelberg University · DEInstitute of Haematology and Blood Transfusion · CZInstitut Paoli-Calmettes · FRInstitutul Clinic Fundeni · ROIPO Porto · PTIRCCS Ospedale San Raffaele · ITLeiden University Medical Center · NLMedical University of South Carolina · USNational Cancer Institute · USTechnische Universität Dresden · DEUniversity College London · GBUniversity Medical Center Groningen · NL

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
NTP INFORMATION SYSTEMS SUPPORT27305C0011 · NIEHS · Z-TECH CORPORATION · 2007 to 2009
$4.3M
PROVIDE RABBITS, RATS, MICE, HAMSTERS, GERBILS, GUINEA PIGS27307C0011 · NIEHS · PI BOLEN, WAYNE · 2007 to 2007
$500k
NCI NIH HHS U24 CA076518NIEHS NIH HHS 27305C0011NIEHS NIH HHS 27307C0011NIEHS NIH HHS 27398C0011
6 · The paper itself

Abstract

Optimizing natural killer (NK) cell alloreactivity could further improve outcome after allogeneic hematopoietic cell transplantation (alloHCT). The donor's Killer-cell Immunoglobulin-like Receptor (KIR) genotype may provide important information in this regard. In the past decade, different models have been proposed aiming at maximizing NK cell activation by activating KIR-ligand interactions or minimizing inhibitory KIR-ligand interactions. Alternative classifications intended predicting outcome after alloHCT by donor KIR-haplotypes. In the present study, we aimed at validating proposed models and exploring more classification approaches. To this end, we analyzed samples stored at the Collaborative Biobank from HLA-compatible unrelated stem cell donors who had donated for patients with acute myeloid leukemia (AML) or myelodysplastic neoplasm (MDS) and whose outcome data had been reported to EBMT or CIBMTR. The donor

Indexed as

Hematopoietic Stem Cell TransplantationHistocompatibilityLeukemia, Myeloid, AcuteMyelodysplastic SyndromesReceptors, KIRGenotypeHumansLigandsMiddle AgedPrognosisLigandsReceptors, KIRallogeneic hematopoietic cell transplantation (alloHCT)donor selectionkiller-cell immunoglobulin-like receptor (KIR)prediction modelrisk of relapse

Identifiers

PMID38629074
PMCPMC11019434
OpenAlexW4393396558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.