Evidence map›Paper›PMID 38628830›Full record

ArticleBasic and clinical neuroscience

Expressional Study of Permeability Glycoprotein and Multidrug Resistance Protein 1 in Drug-resistant Mesial Temporal Lobe Epilepsy.

Mandeep Kaur, Tulika Gupta, Mili Gupta, Navneet Singla, Parampreet S Kharbanda, Yogender Singh Bansal, Daisy Sahni, Bishan Das Radotra, Sunil Kumar Gupta

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic and clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mandeep KaurDepartment of Anatomy, Institute of Medical Education and Research, Chandigarh, India.ORCID https://orcid.org/0000-0001-6431-9414
Tulika GuptaDepartment of Anatomy, Institute of Medical Education and Research, Chandigarh, India.ORCID https://orcid.org/0000-0003-4910-1796
Mili GuptaDepartment of Biochemistry, Singh Judge Institute of Dental Sciences and Hospital, Panjab University, Chandigarh, India.ORCID https://orcid.org/0000-0002-2315-5350
Navneet SinglaDepartment of Neurosurgery, Institute of Medical Education and Research, Chandigarh, India.ORCID https://orcid.org/0000-0003-2685-1981
Parampreet S KharbandaDepartment of Neurology, Institute of Medical Education and Research, Chandigarh, India.
Yogender Singh BansalDepartment of Forensic Medicine, Institute of Medical Education and Research, Chandigarh, India.ORCID https://orcid.org/0000-0002-5752-7968
Daisy SahniDepartment of Anatomy, Institute of Medical Education and Research, Chandigarh, India.ORCID https://orcid.org/0000-0002-0903-0674
Bishan Das RadotraDepartment of Histopathology, Institute of Medical Education and Research, Chandigarh, India.
Sunil Kumar GuptaDepartment of Neurosurgery, Institute of Medical Education and Research, Chandigarh, India.ORCID https://orcid.org/0000-0003-4991-9256
Post Graduate Institute of Medical Education and Research · INPanjab University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: About 30% of patients with epilepsy do not respond to anti-epileptic drugs, leading to refractory seizures. The pathogenesis of drug-resistance in mesial temporal lobe epilepsy (MTLE) is not completely understood. Increased activity of drug-efflux transporters might be involved, resulting in subclinical concentrations of the drug at the target site. The major drug-efflux transporters are permeability glycoprotein ( Methods: We have studied Results: Statistically significant over expression of both Conclusion: Our results suggested that

Indexed as

Drug-efflux transportersDrug-resistant epilepsyMesial temporal lobe epilepsy (MTLE)Multi-drug resistance 1 (MDR1)Multidrug resistance protein 1 (MRP1)Permeability glycoprotein (P-gp

Identifiers

PMID38628830
PMCPMC11016880
OpenAlexW3209288400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.