Evidence map›Paper›PMID 38628794›Full record

ArticleACS medicinal chemistry letters2024

hERG,

Dickson Mambwe, Dina Coertzen, Meta Leshabane, Mwila Mulubwa, Mathew Njoroge, Liezl Gibhard, Gareth Girling, Kathryn J Wicht, Marcus C S Lee, Sergio Wittlin and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dickson MambweDepartment of Chemistry, University of Cape Town, Rondebosch, 7701 Cape Town, South Africa.ORCID https://orcid.org/0000-0003-4910-4479
Dina CoertzenDepartment of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield, 0028 Pretoria, South Africa.
Meta LeshabaneDepartment of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield, 0028 Pretoria, South Africa.
Mwila MulubwaDrug Discovery and Development Centre (H3D), DMPK & Pharmacology, University of Cape Town, Observatory, 7925 Cape Town, South Africa.
Mathew NjorogeDrug Discovery and Development Centre (H3D), DMPK & Pharmacology, University of Cape Town, Observatory, 7925 Cape Town, South Africa.
Liezl GibhardDrug Discovery and Development Centre (H3D), DMPK & Pharmacology, University of Cape Town, Observatory, 7925 Cape Town, South Africa.
Gareth GirlingWellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, United Kingdom.
Kathryn J WichtDepartment of Chemistry, University of Cape Town, Rondebosch, 7701 Cape Town, South Africa.ORCID https://orcid.org/0000-0001-6145-9956
Marcus C S LeeWellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, United Kingdom.
Sergio WittlinSwiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland.
Diogo Rodrigo Magalhães MoreiraCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (Fiocruz), Instituto Gonçalo Moniz, CEP 40296-710 Salvador, Brazil.ORCID https://orcid.org/0000-0003-3323-4404
Lyn-Marie BirkholtzDepartment of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield, 0028 Pretoria, South Africa.ORCID https://orcid.org/0000-0001-5888-2905
Kelly ChibaleDepartment of Chemistry, University of Cape Town, Rondebosch, 7701 Cape Town, South Africa.ORCID https://orcid.org/0000-0002-1327-4727

Funding

New tools for antimalarial target identificationR01AI143521 · NIAID · UNIVERSITY OF CAPE TOWN · PI WICHT, KATHRYN JEAN · 2019 to 2023
$709k
NIAID NIH HHS R01 AI143521
6 · The paper itself

Abstract

Toward addressing the cardiotoxicity liability associated with the antimalarial drug astemizole (AST, hERG IC

Identifiers

PMID38628794
PMCPMC11017395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.