The antiapoptotic effects of conditioned medium from bone marrow-derived mesenchymal stromal stem cells on cyclophosphamide-induced testicular damage in rat: An experimental study.

Zeynab Esmailpour, Soheila Madadi, Maryam Baazm

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Article in International journal of reproductive biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.5field-weighted citation impact, top 32% of its field

1 · What the graph read from it

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0 citing papers in PubMed, 1 citations in OpenAlex.

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5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Zeynab EsmailpourStudents Research Committee, Arak University of Medical Sciences, Arak, Iran.

Soheila MadadiDepartment of Anatomy, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.

Maryam BaazmDepartment of Anatomy, School of Medicine, Arak University of Medical Sciences, Arak, Iran.ORCID https://orcid.org/0000-0002-1248-6314

Arak University of Medical Sciences · IRJahrom University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cyclophosphamide (CP) has some negative effects on the reproductive system. Stem cells and their metabolites are being utilized to enhance fertility after chemotherapy. Objective: This study aimed to investigate the impact of conditioned medium (CM) derived from bone marrow mesenchymal stromal stem cells (BM-MSCs) on the toxic effects of CP on testicles. Materials and Methods: BM-MSCs were isolated, a CM was collected and 25-fold concentrated. 24 male Wistar rats (8 wk, 200-250 gr) were randomly divided into following groups: control, CP, CP+ Dulbecco's Modified Eagle Medium (DMEM), CP+CM. CP was given at a single dose of 100 mg/kg. 2 wk after the CP administration, CM was injected into the testicular efferent duct. Sperm parameters, testicular histopathology, and the level of testosterone were analyzed 2 months after treatment. The expression of B-cell lymphoma 2 ( Results: CP had a negative effect on testis histology (p Conclusion: These findings suggest that CM produced from BM-MSCs may be valuable for therapeutic approaches in reproductive medicine and may lessen the side effects of CP.

Indexed as

ApoptosisBone marrow mesenchymal stem cellsConditioned mediumCyclophosphamideSpermatogenesis.

Identifiers

PMID38628779

DOI10.18502/ijrm.v22i2.15706

PMCPMC11017209

OpenAlexW4393144004

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