Evidence map›Paper›PMID 38628559›Full record

ArticleMolecular and clinical oncology2024

Causal relationship between gut microbiota and gastric cancer: A two‑sample Mendelian randomization analysis.

Jianling Zhang, Chunlu Dong, Yanyan Lin, Lifeng Shang, Junming Ma, Ruiping Hu, Hejing Wang

Open access · diamondAbstract read
In one paragraph

Article in Molecular and clinical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Editorial: Advances in the microbiome, immunity and cancer interplay.Frontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jianling ZhangGeneral Surgery Ward 5, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Chunlu DongGeneral Surgery Ward 3, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Yanyan LinGeneral Surgery Ward 3, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Lifeng ShangDepartment of General Surgery, Qingdao Eighth People's Hospital, Qingdao, Shandong 266000, P.R. China.
Junming MaDepartment of General Surgery, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia 750000, P.R. China.
Ruiping HuDepartment of Endocrinology, The Third People's Hospital of Gansu Province, Lanzhou, Gansu 730000, P.R. China.
Hejing WangDepartment of Healthcare-Associated Infection Control, The Third People's Hospital of Gansu Province, Lanzhou, Gansu 730000, P.R. China.
Lanzhou University · CNFirst Hospital of Lanzhou University · CNQingdao Eighth People's Hospital · CNThe Fourth People's Hospital of Ningxia Hui Autonomous Region · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota is associated with GC; however, the causal association between the gut microbiota and GC remains to be determined. The aim of the present study was to investigate the causal association between gut microbiota and gastric cancer (GC) from the perspective of Mendelian randomization (MR). The present study performed MR analysis using summary statistics from a genome-wide association study of the gut microbiome and GC. Inverse-variance weighted, MR-Egger and weighted median methods were used to investigate the causal relationship between gut microbiota and GC. Heterogeneity tests were performed using Cochrane's Q statistic. Horizontal polytropy was detected using Mendelian Randomization Pleiotropy RESidual Sum and Outlier were eliminated. Estimates from MR indicated that nine gut microorganism remained stable with regard to acceptance of heterogeneity and sensitivity methods. Among them, the genera

Indexed as

causal relationshipgastric cancergenome-wide association studygut microbiotaMendelian randomization

Identifiers

PMID38628559
PMCPMC11019462
OpenAlexW4393438028

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.