ArticleRSC advances2024
Detection of SARS-CoV-2 N protein using AgNPs-modified aligned silicon nanowires BioSERS chip.
Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Gold-Decorated Oxidized Porous Silicon Nanoscaffolds as SERS Platform for Plasmonic Pesticide Sensing.ACS omega · 2026Article
- Surfactant-Induced Interfacial Anisotropy Governs Polarization-Selective Whispering Gallery Mode Excitation in Dye-Doped Trapped Microdroplets.ACS omega · 2026Article
- Horseradish peroxidase assisted "signal-on" chemiluminescence aptasensor for sensitive detection of aflatoxin B1.RSC advances · 2026Article
- Harnessing the Power of Plasmonics forACS photonics · 2025Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The SARS-CoV-2 (COVID-19) pandemic had a strong impact on societies and economies worldwide and tests for high-performance detection of SARS-CoV-2 biomarkers are still needed for potential future outbreaks of the disease. In this paper, we present the different steps for the design of an aptamer-based surface-enhanced Raman scattering (BioSERS) sensing chip capable of detecting the coronavirus nucleocapsid protein (N protein) in spiked phosphate-buffered solutions and real samples of human blood serum. Optimization of the preparation steps in terms of the aptamer concentration used for the functionalization of the silver nanoparticles, time for affixing the aptamer, incubation time with target protein, and insulation of the silver active surface with cysteamine, led to a sensitive BioSERS chip, which was able to detect the N protein in the range from 1 to 75 ng mL
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Registered trials
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