Evidence map›Paper›PMID 38627946›Full record

ArticleJNCI cancer spectrum2024

Diet quality and cardiovascular disease risk among breast cancer survivors in the Pathways Study.

Isaac J Ergas, Richard K Cheng, Janise M Roh, Lawrence H Kushi, Jacob K Kresovich, Carlos Iribarren, Mai Nguyen-Huynh, Jamal S Rana, Eileen Rillamas-Sun, Cecile A Laurent and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JNCI cancer spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Isaac J ErgasDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID 0000-0002-3187-9754
Richard K ChengUniversity of Washington Medical Center, Seattle, WA, USA.
Janise M RohDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID 0000-0002-8615-4320
Lawrence H KushiDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Jacob K KresovichH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Carlos IribarrenDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID 0000-0001-5622-1839
Mai Nguyen-HuynhDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Jamal S RanaDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Eileen Rillamas-SunDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Cecile A LaurentDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Valerie S LeeDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Charles P QuesenberryDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Heather GreenleeUniversity of Washington Medical Center, Seattle, WA, USA.
Marilyn L KwanDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Kaiser Permanente · USUniversity of Washington Medical Center · USFred Hutch Cancer Center · USMoffitt Cancer Center · US

Funding

Prospective Study of Breast Cancer SurvivorshipR01CA105274 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI KUSHI, LAWRENCE H · 2004 to 2014
$19.9M
Infrastructure for Pathways, a Prospective Study of Breast Cancer SurvivorshipU01CA195565 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI AMBROSONE, CHRISTINE B., KUSHI, LAWRENCE H · 2016 to 2025
$18.8M
Predictors of CVD among breast cancer survivors in an integrated health systemR01CA214057 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI GREENLEE, HEATHER, KWAN, MARILYN L · 2017 to 2020
$2.6M
Developing CVD prediction models for women with early stage breast cancerU01CA214057 · NCI · FRED HUTCHINSON CANCER CENTER · PI Heather Greenlee · 2025 to 2026
$1.5M
NCI NIH HHS R01 CA105274NCI NIH HHS R01 CA214057NCI NIH HHS R01CA214057NCI NIH HHS U01 CA195565NCI NIH HHS U01 CA214057
6 · The paper itself

Abstract

backgroundWomen with breast cancer are at higher risk of cardiovascular disease (CVD) compared with women without breast cancer. Whether higher diet quality at breast cancer diagnosis lowers this risk remains unknown. We set out to determine if higher diet quality at breast cancer diagnosis was related to lower risk of CVD and CVD-related death.

methodsThis analysis included 3415 participants from the Pathway Study, a prospective cohort of women diagnosed with invasive breast cancer at Kaiser Permanente Northern California between 2005 and 2013 and followed through December 31, 2021. Scores from 5 diet quality indices consistent with healthy eating were obtained at the time of breast cancer diagnosis. Scores were categorized into ascending quartiles of concordance for each diet quality index, and multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated. P values were 2-sided.

resultsThe Dietary Approaches to Stop Hypertension diet quality index was associated with lower risk of heart failure (HR = 0.53, 95% CI = 0.33 to 0.87; Ptrend = .03), arrhythmia (HR = 0.77, 95% CI = 0.62 to 0.94; Ptrend = .008), cardiac arrest (HR = 0.77, 95% CI = 0.61 to 0.96; Ptrend = .02), valvular heart disease (HR = 0.79, 95% CI = 0.64 to 0.98; Ptrend = .046), venous thromboembolic disease (HR = 0.75, 95% CI = 0.60 to 0.93; Ptrend = .01), and CVD-related death (HR = 0.70, 95% CI = 0.50 to 0.99; Ptrend = .04), when comparing the highest with lowest quartiles. Inverse associations were also found between the healthy plant-based dietary index and heart failure (HR = 0.60, 95% CI = 0.39 to 0.94; Ptrend = .02), as well as the alternate Mediterranean dietary index and arrhythmia (HR = 0.74, 95% CI = 0.60 to 0.93; Ptrend = .02).

conclusionAmong newly diagnosed breast cancer patients, higher diet quality at diagnosis was associated with lower risk of CVD events and death.

Indexed as

Breast NeoplasmsCancer SurvivorsCardiovascular DiseasesHeart FailureArrhythmias, CardiacDietFemaleHumansProspective Studies

Identifiers

PMID38627946
PMCPMC11021810
OpenAlexW4394870305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.