Evidence map›Paper›PMID 38627829›Full record

ReviewMolecular neurodegeneration2024

Gut microbiota-host lipid crosstalk in Alzheimer's disease: implications for disease progression and therapeutics.

Ya-Xi Luo, Ling-Ling Yang, Xiu-Qing Yao

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular neurodegeneration, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ya-Xi Luo *Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ling-Ling Yang *Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xiu-Qing YaoDepartment of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. dryaoxq@cqmu.edu.cn.ORCID 0000-0002-0292-2792
Dalian Medical University · CN

Funding

Chongqing Medical University No. kryc-lj-2105National Natural Science Foundation of China No.82371427Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission CSTB2023NSCQBHX0018Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission CSTB2023NSCQ-MSX0323
6 · The paper itself

Abstract

Trillions of intestinal bacteria in the human body undergo dynamic transformations in response to physiological and pathological changes. Alterations in their composition and metabolites collectively contribute to the progression of Alzheimer's disease. The role of gut microbiota in Alzheimer's disease is diverse and complex, evidence suggests lipid metabolism may be one of the potential pathways. However, the mechanisms that gut microbiota mediate lipid metabolism in Alzheimer's disease pathology remain unclear, necessitating further investigation for clarification. This review highlights the current understanding of how gut microbiota disrupts lipid metabolism and discusses the implications of these discoveries in guiding strategies for the prevention or treatment of Alzheimer's disease based on existing data.

Indexed as

Alzheimer DiseaseGastrointestinal MicrobiomeDisease ProgressionHumansLipid MetabolismLipidsLipidsAlzheimer’s diseaseAPOECholesterolExerciseGut microbiotaLifestyleLipid metabolismLPSNeuroinflammationProbioticsSCFAs

Identifiers

PMID38627829
PMCPMC11020986
OpenAlexW4394837461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.