ArticleNature medicine2024
Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes.
Article in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Decoding the molecular landscape of the placenta in maternal diabetes: a systematic review of high-throughput data.Journal of molecular endocrinology · 2026Pooled it
- The triglyceride glucose-body mass index and the risk of gestational diabetes mellitus: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Article
- Trimester-specific reference interval for glycated hemoglobin in non-diabetic pregnant women: A cross-sectional study.Clinics (Sao Paulo, Brazil) · 2026Article
- Redox Imbalance in Gestational Diabetes Mellitus: Mechanistic Insights, Emerging Biomarkers, and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Long-read assembly reveals vast transcriptional complexity in the placenta associated with metabolic and endocrine function.Nature communications · 2026Article
- Placental expression of GKN1 and diminished pancreatic beta cell function during pregnancy.Diabetologia · 2026Article
- The Double-Edged Sword of Gestational Insulin Resistance: Navigating Maternal Adaptation and Its Risks for Pregnancy and Offspring Health.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- LASSO regression-derived first-trimester (9-14Archives of gynecology and obstetrics · 2026Article
- Fetal sex-specific differences in the placental transcriptome of gestational diabetes.Scientific reports · 2026Observational
- Exploration of Early Biomarkers for Gestational Diabetes Mellitus in Pregnant Women Living Without Obesity.Journal of diabetes research · 2026Article
- Dual-center prospective validation of an early second-trimester predictive model integrating BMI trajectories and pathophysiological biomarkers for gestational diabetes risk stratification.Journal of diabetes investigation · 2026Article
- Maternal per- and polyfluoroalkyl substances exposure and the co-occurrence of gestational diabetes mellitus and preeclampsia/eclampsia: a nested case-control study.Frontiers in public health · 2026Article
- Trimester-specific gestational weight gain and adverse outcomes in GDM women: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- The association of parental use of new tobacco products and combustible cigarettes with nausea and vomiting in pregnancy: a cross-sectional study.Environmental health and preventive medicine · 2026Article
- Emerging biomarkers for gestational diabetes mellitus and related pediatric outcomes.World journal of clinical pediatrics · 2025Review
- Novel role of NR1D1 and SLC7A5 in gestational diabetes mellitus: regulation of polyamine metabolism.Journal of diabetes and metabolic disorders · 2025Article
- Discovery of placental microRNAs associated with maternal insulin sensitivity during pregnancy.Placenta · 2025Article
- Perillaldehyde Attenuates Insulin Resistance and High Glucose-Induced Ferroptosis in Trophoblast Cells via Regulation of PTPN1/Akt/Foxo1 Signaling Pathway.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Integrating transcriptomic and epigenomic data to identify potential biomarkers in gestational diabetes mellitus patients.Scientific reports · 2025Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
Reduced insulin sensitivity (insulin resistance) is a hallmark of normal physiology in late pregnancy and also underlies gestational diabetes mellitus (GDM). We conducted transcriptomic profiling of 434 human placentas and identified a positive association between insulin-like growth factor binding protein 1 gene (IGFBP1) expression in the placenta and insulin sensitivity at ~26 weeks gestation. Circulating IGFBP1 protein levels rose over the course of pregnancy and declined postpartum, which, together with high gene expression levels in our placenta samples, suggests a placental or decidual source. Higher circulating IGFBP1 levels were associated with greater insulin sensitivity (lesser insulin resistance) at ~26 weeks gestation in the same cohort and in two additional pregnancy cohorts. In addition, low circulating IGFBP1 levels in early pregnancy predicted subsequent GDM diagnosis in two cohorts of pregnant women. These results implicate IGFBP1 in the glycemic physiology of pregnancy and suggest a role for placental IGFBP1 deficiency in GDM pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.