Evidence map›Paper›PMID 38627399›Full record

ArticleNature communications2024

Insights into the inhibition of protospacer integration via direct interaction between Cas2 and AcrVA5.

Mingfang Bi, Wenjing Su, Jiafu Li, Xiaobing Mo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mingfang BiCollege of Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, China.
Wenjing SuCollege of Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, China.
Jiafu LiCollege of Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, China.
Xiaobing MoCollege of Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, China. mox@jlu.edu.cn.ORCID http://orcid.org/0000-0001-9580-6178
Jilin University · CNJilin University of Finance and Economics · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32071476
6 · The paper itself

Abstract

Spacer acquisition step in CRISPR-Cas system involves the recognition and subsequent integration of protospacer by the Cas1-Cas2 complex in CRISPR-Cas systems. Here we report an anti-CRISPR protein, AcrVA5, and reveal the mechanisms by which it strongly inhibits protospacer integration. Our biochemical data shows that the integration by Cas1-Cas2 was abrogated in the presence of AcrVA5. AcrVA5 exhibits low binding affinity towards Cas2 and acetylates Cas2 at Lys

Indexed as

CRISPR-Associated ProteinsCRISPR-Cas SystemsCRISPR-Associated Proteins

Identifiers

PMID38627399
PMCPMC11021501
OpenAlexW4394854667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.