ArticleNature communications2024
Photocatalytic Z/E isomerization unlocking the stereodivergent construction of axially chiral alkene frameworks.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Temperature-controlled conformational switching of squaramides enabled by side-chain hydrogen bonding.RSC advances · 2026Article
- Dynamic palladium catalysis enables chiral amplification toward acyclic Schiff base atropisomers.Nature communications · 2026Article
- Application of Asymmetric Catalysis in theJournal of the American Chemical Society · 2025Article
- Keto-enol tautomerism as dynamic electron/hole traps promote charge carrier separation for hydrogen peroxide photosynthesis.Nature communications · 2025Article
- Stereospecific positional alkene isomerization enables bidirectional central-to-axial chirality transfer.Nature communications · 2025Article
- Divergent Synthesis of Chiroptical Molecular Switches Based on 1,2-Diaxial Atropisomers.JACS Au · 2024Article
- Design and Preparation of Heterostructured CuMolecules (Basel, Switzerland) · 2024Review
- A green Heck reaction protocol towards trisubstituted alkenes, versatile pharmaceutical intermediates.Frontiers in chemistry · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The past century has witnessed a large number of reports on the Z/E isomerization of alkenes. However, the vast majority of them are still limited to the isomerization of di- and tri-substituted alkenes. The stereospecific Z/E isomerization of tetrasubstituted alkenes remains to be an underdeveloped area, thus lacking in a stereodivergent synthesis of axially chiral alkenes. Herein we report the atroposelective synthesis of tetrasubstituted alkene analogues by asymmetric allylic substitution-isomerization, followed by their Z/E isomerization via triplet energy transfer photocatalysis. In this regard, the stereodivergent synthesis of axially chiral N-vinylquinolinones is achieved efficiently. Mechanistic studies indicate that the benzylic radical generation and distribution are two key factors for preserving the enantioselectivities of axially chiral compounds.
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Registered trials
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