ArticleSleep & breathing = Schlaf & Atmung2024
The CORE syndrome: an overlap of severe asthma, obstructive sleep apnea, rhinosinusitis, and esophageal reflux.
Article in Sleep & breathing = Schlaf & Atmung, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Identification of Comorbidities in Obstructive Sleep Apnea Using Diverse Data and a One-Dimensional Convolutional Neural Network.Sensors (Basel, Switzerland) · 2026Observational
- Clinical and psychosocial variables influencing preoperative anxiety in patients undergoing sinus surgery.American journal of translational research · 2026Article
- Rating Scales for Obstructive Sleep Apnea Syndrome: The Importance of a Comprehensive Assessment.Cureus · 2026Review
- Severe Asthma and Sleep Disorders: A Severe Asthma Network Italy (SANI) Registry Analysis.Journal of asthma and allergy · 2025Article
- The Impact of Lung Function on Sleep Monitoring in Obstructive Sleep Apnea Associated with Obstructive Lung Diseases: Insights from a Clinical Study.Journal of clinical medicine · 2024Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAsthma, obstructive sleep apnea (OSA), rhinosinusitis, and esophageal reflux are conditions that may overlap, forming a syndrome known as CORE. Whenever clinical remission of severe asthma (SA) is not achieved, it is essential to investigate the presence of comorbidities, in particular the presence of OSA that may lead to the diagnosis of CORE syndrome.
methodsThe study was conducted on naive patients with SA and concomitant rhinosinusitis and esophageal reflux, referred to our institute since 2018. Patients who did not experience clinical remission were investigated for OSA through a home sleep apnea test. Subsequently, for those diagnosed with OSA, continuous positive airway pressure (CPAP) was proposed and was re-evaluated after 12 months.
resultsSix patients with CORE syndrome were enrolled. The mean apnea-hypopnea index (AHI) was 33.25 ± 20.13 events/h, oxygen desaturation index (ODI) was 28.95 ± 19.95 events/h, and time in bed with SaO2 < 90% (T
conclusionWhenever facing SA patients, non-responders to therapy, it is important to suspect the presence of CORE syndrome; in particular, the detection and subsequent treatment of OSA would seem to improve the outcome of such patients.
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