Evidence map›Paper›PMID 38627262›Full record

ArticlePflugers Archiv : European journal of physiology2024

Functional expression of the proton sensors ASIC1a, TMEM206, and OGR1 together with BK

Karolos-Philippos Pissas, Stefan Gründer, Yuemin Tian

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Karolos-Philippos PissasInstitute of Physiology, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
Stefan GründerInstitute of Physiology, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany. sgruender@ukaachen.de.ORCID 0000-0002-7635-9883
Yuemin TianInstitute of Physiology, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
RWTH Aachen University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fast growing solid tumors are frequently surrounded by an acidic microenvironment. Tumor cells employ a variety of mechanisms to survive and proliferate under these harsh conditions. In that regard, acid-sensitive membrane receptors constitute a particularly interesting target, since they can affect cellular functions through ion flow and second messenger cascades. Our knowledge of these processes remains sparse, however, especially regarding medulloblastoma, the most common pediatric CNS malignancy. In this study, using RT-qPCR, whole-cell patch clamp, and Ca

Indexed as

Acid Sensing Ion ChannelsMedulloblastomaReceptors, G-Protein-CoupledCalciumCell DeathCell Line, TumorCell SizeCerebellar NeoplasmsChloride ChannelsHumansHydrogen-Ion ConcentrationLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsAcid Sensing Ion ChannelsASIC1 protein, humanCalciumChloride ChannelsGPR68 protein, humanKCNMA1 protein, humanLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsPACC1 protein, humanReceptors, G-Protein-CoupledCell deathCell volume regulationExtracellular acidityIon channelsMedulloblastomaTumour microenvironment

Identifiers

PMID38627262
PMCPMC11139714
OpenAlexW4394857366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.