Evidence map›Paper›PMID 38626958›Full record

ArticleBMJ open2024

Multicentre double-blind randomised placebo-controlled trial evaluating the efficacy of the meningococcal B vaccine, 4CMenB (Bexsero), against

Kate L Seib, Basil Donovan, Caroline Thng, David A Lewis, Anna McNulty, Christopher K Fairley, Barbara Yeung, Fengyi Jin, Doug Fraser, Benjamin R Bavinton and 9 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04415424 (A Multi-centre Randomised Controlled Trial Evaluating the Efficacy of the Four-component Meningococcal B Vaccine, 4CMenB), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04415424 phase3active not recruitingnot on this map

A Multi-centre Randomised Controlled Trial Evaluating the Efficacy of the Four-component Meningococcal B Vaccine, 4CMenB (Bexsero®), in the Prevention of Neisseria Gonorrhoeae Infection in Gay and Bisexual Men

TypeinterventionalSponsorKirby InstituteRan2021 to 2025Enrolled650ConditionsNeisseria Gonorrheae InfectionArms4CMenB vaccine, Placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Cabotegravir Maintains Protective Efficacy in the Setting of Bacterial Sexually Transmitted Infections: A Secondary Analysis of HPTN 083.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 3 countries.

Kate L SeibInstitute for Glycomics, Griffith University, Gold Coast, Queensland, Australia k.seib@griffith.edu.au.ORCID 0000-0002-7094-3528
Basil DonovanThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Caroline ThngInstitute for Glycomics, Griffith University, Gold Coast, Queensland, Australia.
David A LewisWestern Sydney Sexual Health Centre, Sydney, New South Wales, Australia.
Anna McNultySydney Sexual Health Centre, Sydney, New South Wales, Australia.
Christopher K FairleyMelbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.
Barbara YeungThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Fengyi JinThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Doug FraserThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Benjamin R BavintonThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Matthew LawThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Marcus Y ChenMelbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.
Eric P F ChowMelbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.
David M WhileyUQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Brent MackieACON Health, Sydney, New South Wales, Australia.
Michael P JenningsInstitute for Glycomics, Griffith University, Gold Coast, Queensland, Australia.
Amy V JennisonPublic Health Microbiology, Queensland Health Forensic and Scientific Services, Brisbane, Queensland, Australia.ORCID 0000-0002-5599-7480
Monica M LahraWHO Collaborating Centre for STI and AMR, New South Wales Health Pathology Microbiology, The Prince of Wales Hospital, Sydney, New South Wales, Australia.
Andrew E GrulichThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0002-3269-1032
UNSW Sydney · AUAustralian Regenerative Medicine Institute · AUGriffith University · AUNepean Hospital · AUQueensland Health · AUThe University of Queensland · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGonorrhoea, the sexually transmissible infection caused by METHODS AND ANALYSIS: This is a double-blind, randomised placebo-controlled trial in GBM+, either HIV-negative on pre-exposure prophylaxis against HIV or living with HIV (CD4 count >350 cells/mm ETHICS AND DISSEMINATION: Ethical approval was obtained from the St Vincent's Hospital Human Research Ethics Committee, St Vincent's Hospital Sydney, NSW, Australia (ref: 2020/ETH01084). Results will be disseminated in peer-reviewed journals and via presentation at national and international conferences. TRIAL REGISTRATION NUMBER: NCT04415424.

Indexed as

Anti-Infective AgentsGonorrheaHIV InfectionsMeningococcal InfectionsMeningococcal VaccinesSexual and Gender MinoritiesHomosexuality, MaleHumansMaleMulticenter Studies as TopicNeisseria gonorrhoeaeRandomized Controlled Trials as Topic4CMenB vaccineAnti-Infective AgentsMeningococcal VaccinesClinical TrialIMMUNOLOGYMICROBIOLOGYSexually Transmitted DiseaseVaccination

Identifiers

PMID38626958
PMCPMC11029339
OpenAlexW4394859385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.