Evidence map›Paper›PMID 38626900›Full record

GuidelineThrombosis and haemostasis2024

Practical Suggestions for an Optimal Management of Vitamin K Antagonists: Italian Federation of Centers for the Diagnosis of Thrombotic Disorders and the Surveillance of the Antithrombotic Therapies (FCSA) Position Paper.

Silvia Galliazzo, Paolo Bucciarelli, Doris Barcellona, Antonio Ciampa, Elvira Grandone, Giuseppe Malcangi, Giuseppe Rescigno, Alessandro Squizzato, Vincenzo Toschi, Sophie Testa and 1 more

Open access · hybridAbstract readPractice GuidelineReview
In one paragraph

Guideline in Thrombosis and haemostasis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Silvia GalliazzoResearch Center on Thromboembolic Disorders and Antithrombotic Therapies, University of Insubria, Sant'Anna Hospital, ASST Lariana, Como, Italy.
Paolo BucciarelliAngelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.
Doris BarcellonaThrombosis and Haemostasis Unit, University of Cagliari, Cagliari, Italy.ORCID 0000-0002-0823-3357
Antonio CiampaHaemostasis Center, AORN S.G. Moscati, Avellino, Italy.
Elvira GrandoneThrombosis and Haemostasis Unit, IRCCS, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Giuseppe MalcangiHaemophilia and Thrombosis Center, AOU Policlinico, Bari, Italy.
Giuseppe RescignoHaemostasis and Thrombosis Center, DEA P.O. "Umberto I," Nocera Inferiore, Salerno, Italy.
Alessandro SquizzatoResearch Center on Thromboembolic Disorders and Antithrombotic Therapies, University of Insubria, Sant'Anna Hospital, ASST Lariana, Como, Italy.ORCID 0000-0001-5705-2897
Vincenzo ToschiDepartment of Haematology and Blood Transfusion and Thrombosis Center, Santi Paolo e Carlo Hospital, Milan, Italy.
Sophie TestaHaemostasis and Thrombosis Center, ASST Cremona, Cremona, Italy.
Daniela PoliThrombosis Center, 'Careggi' Hospital, Florence, Italy.
University of Insubria · ITAzienda Ospedaliera S.Giuseppe Moscati · ITAzienda Ospedaliero-Universitaria Careggi · ITCasa Sollievo della Sofferenza · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITIstituti Ospitalieri di Cremona · ITOspedali Riuniti Umberto I · ITUniversity of Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the era of direct oral anticoagulants, vitamin K antagonists retain a clinically relevant role in thrombotic disorders. In Italy, approximately 20% of the patients on anticoagulant therapies receives a VKA, in most cases warfarin. The optimal management of this drug is challenging and cannot disregard its intricate and unpredictable pharmacokinetic properties and patient's thrombotic and bleeding risk. Several clinical issues encountered during warfarin treatment are still unanswered and are tentatively addressed by physicians. In this regard, the Italian Federation of Centers for the diagnosis of thrombotic disorders and the Surveillance of the Antithrombotic therapies (FCSA) provides some experience-based good clinical practice's suggestions on the following topics: (1) how to start the anticoagulant treatment with warfarin and warfarin induction regimen; (2) how to manage a subtherapeutic INR value; (3) how to manage a supratherapeutic INR value in asymptomatic patients; and (4) how to manage the association of warfarin with interfering drugs.

Indexed as

AnticoagulantsHemorrhageInternational Normalized RatioThrombosisVitamin KWarfarinBlood CoagulationDrug InteractionsDrug MonitoringFibrinolytic AgentsHumansItalyAnticoagulantsFibrinolytic AgentsVitamin KWarfarin

Identifiers

PMID38626900
PMCPMC11259493
OpenAlexW4394840246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.