SynthesisPloS one2024
Chest pain in pediatric patients in the emergency department- Presentation, risk factors and outcomes-A systematic review and meta-analysis.
Synthesis in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Predictors of Hospital Admission and Cardiac Diagnosis in Children Presenting with Chest Pain: The Role of Recurrent Presentation and Inflammatory Markers.Medicina (Kaunas, Lithuania) · 2026Article
- Children and young people tested for vitamin D deficiency and insufficiency at a busy children's emergency department in Birmingham, UK: an observational study.BMJ paediatrics open · 2026Observational
- Review
- The readability and quality paradox: Comparing ChatGPT, Gemini, and Perplexity outputs on pediatric chest pain queries.PloS one · 2026Article
- Incidence, Diagnoses, and Outcomes of Pediatric Nontraumatic Chest Pain Attended by Ambulance.JAMA network open · 2025Article
- The Utility of Troponin in Predicting Cardiac Dysfunction in Pediatric Patients: A Meta-Analysis.Cureus · 2025Review
- False Troponin Elevation in Pediatric Patients: A Long-Term Biochemical Conundrum Without Cardiac Effects.Diagnostics (Basel, Switzerland) · 2025Article
- Missed or Delayed Diagnosis of Heart Disease by the General Pediatrician.Children (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to assess and determine the presentation, risk factors, and outcomes of pediatric patients who were admitted for cardiac-related chest pain.
backgroundAlthough chest pain is common in children, most cases are due to non-cardiac etiology. The risk of misdiagnosis and the pressure of potentially adverse outcomes can lead to unnecessary diagnostic testing and overall poorer patient experiences. Additionally, this can lead to a depletion of resources that could be better allocated towards patients who are truly suffering from cardiac-related pathology.
methodsThis review was conducted per PRISMA guidelines. This systematic review used several databases including MEDLINE, Embase, Scopus, and Web of Science to obtain its articles for review.
resultsA total of 6,520 articles were identified, and 11 articles were included in the study. 2.5% of our study population was found to have cardiac-related chest pain (prevalence = 0.025, 95% CI [0.013, 0.038]). The most commonly reported location of pain was retrosternal chest pain. 97.5% of the study population had a non-cardiac cause of chest pain, with musculoskeletal pain being identified as the most common cause (prevalence = 0.357, 95% CI [0.202, 0.512]), followed by idiopathic (prevalence = 0.352, 95% CI [0.258, 0.446]) and then gastrointestinal causes (prevalence = 0.053, 95% CI [0.039, 0.067]).
conclusionsThe overwhelming majority of pediatric chest pain cases stem from benign origins. This comprehensive analysis found musculoskeletal pain as the predominant culprit behind chest discomfort in children. Scrutinizing our study cohort revealed that retrosternal chest pain stands as the unequivocal epicenter of this affliction. Thorough evaluation of pediatric patients manifesting with chest pain is paramount for the delivery of unparalleled care, especially in the context of potential cardiac risks in the emergency department.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.