Evidence map›Paper›PMID 38625941›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Tight-packing of large pilin subunits provides distinct structural and mechanical properties for the

Anke Treuner-Lange, Weili Zheng, Albertus Viljoen, Steffi Lindow, Marco Herfurth, Yves F Dufrêne, Lotte Søgaard-Andersen, Edward H Egelman

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 15 citations in OpenAlex.

  1. β-strand addition within tip initiation complexes licenses assembly of diverse type IV filaments.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  9. Milestones in the development ofJournal of bacteriology · 2025
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  16. Tad and toxin-coregulated pilus structures reveal unexpected diversity in bacterial type IV pili.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Anke Treuner-LangeDepartment of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany.ORCID 0000-0001-6435-5642
Weili ZhengDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903.
Albertus ViljoenLouvain Institute of Biomolecular Science and Technology, UCLouvain, Louvain-la-Neuve B-1348, Belgium.ORCID 0000-0001-8949-7401
Steffi LindowDepartment of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany.
Marco HerfurthDepartment of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany.ORCID 0000-0003-4291-0283
Yves F DufrêneLouvain Institute of Biomolecular Science and Technology, UCLouvain, Louvain-la-Neuve B-1348, Belgium.
Lotte Søgaard-AndersenDepartment of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany.ORCID 0000-0002-0674-0013
Edward H EgelmanDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903.ORCID 0000-0003-4844-5212
Max Planck Institute for Terrestrial Microbiology · DEUCLouvain · BEUniversity of Virginia · US

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jay William FOX · 1987 to 2026
$72.1M
Cryo-EM of Helical Protein and Nucleoprotein Polymers at Near Atomic ResolutionR35GM122510 · NIGMS · UNIVERSITY OF VIRGINIA · PI EDWARD H. EGELMAN · 2017 to 2026
$7.3M
NCI NIH HHS P30 CA044579NIGMS NIH HHS R35 GM122510
6 · The paper itself

Abstract

Type IVa pili (T4aP) are ubiquitous cell surface filaments important for surface motility, adhesion to surfaces, DNA uptake, biofilm formation, and virulence. T4aP are built from thousands of copies of the major pilin subunit and tipped by a complex composed of minor pilins and in some systems also the PilY1 adhesin. While major pilins of structurally characterized T4aP have lengths of <165 residues, the major pilin PilA of

Indexed as

Fimbriae ProteinsMyxococcus xanthusFimbriae, BacterialProtein Structure, SecondaryVirulenceFimbriae Proteinsbacterial motilitycryo-EMintersubunit contactslarge pilinsType IVa pili

Identifiers

PMID38625941
PMCPMC11046646
OpenAlexW4394856583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.