ArticleProceedings of the National Academy of Sciences of the United States of America2024
Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
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Who cites it
16 citing papers in PubMed, 14 citations in OpenAlex.
- Multi-omics profiling reveals homologous recombination repair hyperactivation as a therapeutic vulnerability in neuroendocrine cervical carcinoma.Signal transduction and targeted therapy · 2026Article
- Recent progress and therapeutic strategies in the treatment of cervical neuroendocrine neoplasms (Review).International journal of molecular medicine · 2026Review
- Article
- When Immunophenotype Is Not Identity: A Clinicopathological Review of Neuroendocrine Differentiation in Tumors of the Female Genital Tract.Diagnostics (Basel, Switzerland) · 2026Review
- Whole-Exome Profiling of Epstein-Barr Virus-Positive Neuroendocrine Carcinoma of the Nasopharynx.Endocrine pathology · 2026Article
- A Retrospective Study on the Clinicopathological Characteristics and Prognostic Analysis of Gynecologic Neuroendocrine Carcinoma.Cancer medicine · 2026Observational
- Novel HSPA8-NR4A2 rearrangement in extraskeletal myxoid chondrosarcoma: a sarcoma mimicker of neuroendocrine neoplasia.Virchows Archiv : an international journal of pathology · 2025Article
- [Clinicopathological Characteristics of Cervical Neuroendocrine Carcinoma and Their Relationship With Prognosis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Proteomics analysis reveals FEN1 as a promising therapeutic target against small cell neuroendocrine carcinoma of the cervix.Scientific reports · 2025Article
- Single-cell RNA sequencing highlights the unique tumor microenvironment of small cell neuroendocrine cervical carcinoma.Journal of translational medicine · 2025Article
- Risk of Ovarian Metastasis and Prognosis in Patients with Neuroendocrine Carcinoma of the Uterine Cervix: A Multi-Center Retrospective Cohort Study.International journal of women's health · 2025Article
- An unyielding challenge for refractory hyponatremia in neuroendocrine cervix carcinoma: a case report.Frontiers in endocrinology · 2025Article
- Prognostic value of inflammatory markers and different treatment regimens in neuroendocrine cervical carcinoma: a retrospective study.Frontiers in pharmacology · 2025Article
- Immune microenvironment heterogeneity characterizes biologically distinct KRASFrontiers in immunology · 2025Article
- Neuroendocrine transdifferentiation in human cancer: molecular mechanisms and therapeutic targets.MedComm · 2024Review
- The Prognosis of Patients With Large Cell Carcinoma of the Cervix: A Retrospective Study of the SEER Database and a Chinese Multi-Center Registry.Cancer control : journal of the Moffitt Cancer CenterObservational
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Authors and funding
38 authors at 9 institutions in 4 countries.
Stefania Bellone *Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.
Kyungjo Jeong *Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea.
Mari Kyllesø HalleCentre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen 5021, Norway.ORCID 0000-0002-2660-8271
Camilla KrakstadCentre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen 5021, Norway.
Blair McNamaraDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.
Michelle GreenmanDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.
Levent MutluDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.
Cem DemirkiranDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.
Tobias Max Philipp HartwichDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.
Yang Yang-HartwichDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.
Margherita ZipponiDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.
Natalia BuzaDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0002-0008-334X
Pei HuiDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06510.
Francesco RaspagliesiFirst Pathology Division, Fondazione Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori di Milano, Milano 20133, Italy.
Salvatore LopezFirst Pathology Division, Fondazione Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori di Milano, Milano 20133, Italy.
Biagio PaoliniFirst Pathology Division, Fondazione Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori di Milano, Milano 20133, Italy.
Massimo MilioneFirst Pathology Division, Fondazione Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori di Milano, Milano 20133, Italy.
Emanuele PerroneUnit of Gynecologic Oncology, Department Woman and Child Health Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome 00168, Italy.
Giovanni ScambiaUnit of Gynecologic Oncology, Department Woman and Child Health Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome 00168, Italy.
Gary AltwergerDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.
Antonella Ravaggi"Angelo Nocivelli" Institute of Molecular Medicine, Department of Obstetrics and Gynecology, Azienda Socio Sanitaria Territoriale (ASST) Spedali Civili and University of Brescia, Brescia 25123, Italy.ORCID 0000-0003-4661-9979
Eliana Bignotti"Angelo Nocivelli" Institute of Molecular Medicine, Department of Obstetrics and Gynecology, Azienda Socio Sanitaria Territoriale (ASST) Spedali Civili and University of Brescia, Brescia 25123, Italy.ORCID 0000-0001-6380-6181
Gloria S HuangDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0002-0001-888X
Vaagn AndikyanDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0001-9326-0255
Mitchell ClarkDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0003-1118-9585
Elena RatnerDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.
Masoud AzodiDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.
Peter E SchwartzDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0002-0845-3624
Charles M QuickDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205.ORCID 0000-0002-8619-3477
Roberto AngioliDepartment of Obstetrics and Gynecology, Università Campus Bio-Medico di Roma, Rome 00128, Italy.
Corrado TerranovaDepartment of Obstetrics and Gynecology, Università Campus Bio-Medico di Roma, Rome 00128, Italy.
Samir ZaidiDepartment of Genitourinary Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10069.
Shuvro NandiDepartment of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA 92093.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA 92093.ORCID 0000-0003-3596-4515
Eric R SiegelDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR 72205.ORCID 0000-0001-9824-6612
Jungmin ChoiDepartment of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea.ORCID 0000-0002-8614-0973
Joseph SchlessingerDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0002-5085-5969
Alessandro D SantinDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0003-4724-9738
Yale University · USIstituti di Ricovero e Cura a Carattere Scientifico · ITHaukeland University Hospital · NOKorea University · KRUniversità Campus Bio-Medico · ITUniversity of Arkansas for Medical Sciences · USUniversity of Brescia · ITUniversity of California San Diego · USMemorial Sloan Kettering Cancer Center · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0MUncovering the Mechanisms of Metastasis in Fallopian Tube-Originated Ovarian CancerR01CA269779 · NCI · YALE UNIVERSITY · PI Yang Yang-Hartwich · 2022 to 2026
$2.1MIntegrated genomic analysis of racial disparities in endometrial cancerU01CA176067 · NCI · YALE UNIVERSITY · PI SANTIN, ALESSANDRO D · 2014 to 2018
$1.7MHigh Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2MNCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016359NCI NIH HHS R01 CA269779NCI NIH HHS U01 CA176067NIH HHS S10 OD030363
Abstract
High-grade neuroendocrine cervical cancers (NETc) are exceedingly rare, highly aggressive tumors. We analyzed 64 NETc tumor samples by whole-exome sequencing (WES). Human papillomavirus DNA was detected in 65.6% (42/64) of the tumors. Recurrent mutations were identified in
Indexed as
AdenocarcinomaCarcinoma, NeuroendocrineNeuroendocrine TumorsUterine Cervical NeoplasmsAfatinibClass I Phosphatidylinositol 3-KinasesDNA Mutational AnalysisFemaleHumansMutationPhosphatidylinositol 3-KinasesPhylogenyAfatinibClass I Phosphatidylinositol 3-KinasesPhosphatidylinositol 3-Kinasescancergenetic analysismutationsneuroendocrineoncogene
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.