ArticleCell reports2024
Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration.
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Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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Who cites it
22 citing papers in PubMed.
- HSCT in SAVI: evidence for a curative hematopoietic approach and perspectives for gene therapy.Molecular therapy. Advances · 2026Article
- Endothelial cell expression of STINGThe Journal of investigative dermatology · 2026Article
- The cGAS-STING pathway in inflammaging and neuroinflammation.Science China. Life sciences · 2026Review
- DNA Sensing and Neuroinflammation: Mechanistic Insights into cGAS-STING Biology and Therapeutic Translation in Age-Related Neurodegenerative Diseases.Molecular neurobiology · 2026Review
- Autoinflammatory syndromes of STING and TREX1 dysfunction.The Journal of clinical investigation · 2026Review
- Interstitial lung disease and the STING pathway.The Journal of clinical investigation · 2026Review
- FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-κB activation in Drosophila melanogaster.The EMBO journal · 2026Article
- STING-STAT3-SOX18 Axis Drives EndMT and Epigenetic Reprogramming in SAVI Lung Fibrosis.bioRxiv : the preprint server for biology · 2026Article
- SAVI: molecular mechanisms, clinical spectrum and precision medicine approaches beyond type-I IFN.Frontiers in immunology · 2026Review
- Article
- The pathogenesis, clinical presentations and treatment of monogenic systemic vasculitis.Nature reviews. Rheumatology · 2025Review
- PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease.The Journal of experimental medicine · 2025Article
- STING deletion protects against amyloid β-induced Alzheimer's disease pathogenesis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Nucleic acid triggers of autoimmunity and autoinflammation.Current opinion in immunology · 2025Review
- Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling.eLife · 2025Article
- Dynamic STING repression orchestrates immune cell development and function.Science immunology · 2025Article
- DNA-sensing pathways in health, autoinflammatory and autoimmune diseases.Nature immunology · 2024Review
- The commoneLife · 2024Article
- A novel STING variant triggers endothelial toxicity and SAVI disease.The Journal of experimental medicine · 2024Article
- Activation of autoreactive lymphocytes in the lung by radioresistant cells expressing a STING gain-of-function mutation.JCI insight · 2024Article
Corrections and comments
- Update of
Authors and funding
10 authors.
Kevin MingJie GaoDivision of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA; Division of Rheumatology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Kristy ChiangDivision of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA; Division of Rheumatology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Zhaozhao JiangDivision of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Filiz T KorkmazDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Harish P JanardhanDivision of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Chinmay M TrivediDivision of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Lee J QuintonDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Sebastien GingrasDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Katherine A FitzgeraldDivision of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA. Electronic address: kate.fitzgerald@umassmed.edu.
Ann Marshak-RothsteinDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA. Electronic address: ann.rothstein@umassmed.edu.
Funding
Medical Scientist Training at UMMS Administrative SupplementT32GM107000 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIEFE, CATARINA I. · 2013 to 2022
$4.9MEpigenetic regulation of lymphatic developmentR01HL141377 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI TRIVEDI, CHINMAY M · 2018 to 2025
$4.1MRegulation of Cardiac Development by Chromatin Modifying EnzymesR01HL118100 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI TRIVEDI, CHINMAY M · 2013 to 2022
$3.7MMechanisms of STING-driven autoinflammationR01HL165787 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Katherine A. Fitzgerald, Ann Marshak-Rothstein · 2023 to 2026
$3.3MLOX-1 as a protective countermeasure in response to lung infectionR01HL165718 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Lee Quinton · 2023 to 2026
$3.0MRegulation of Lupus by Cytosolic DNA SensorsR01AI128358 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A., MARSHAK-ROTHSTEIN, ANN · 2017 to 2021
$2.7MImmunological Mechanisms in Systemic Autoimmune DiseaseR01AR055634 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MARSHAK-ROTHSTEIN, ANN · 2008 to 2012
$1.8MTraining in the Molecular Basis of Autoimmunity and AutoinflammationT32AI132152 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Katherine A. Fitzgerald, Ann Marshak-Rothstein · 2018 to 2026
$1.6MRadioresistant Innate Immunity in SAVI Tissue-Specific AutoinflammationR21AI178978 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A., MARSHAK-ROTHSTEIN, ANN · 2023 to 2024
$461kEstablishing Mechanisms of LOX-1-Dependent Immune Regulation During PneumoniaK99HL159258 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KORKMAZ, FILIZ · 2022 to 2023
$213kInvestigating the role of B cells in pulmonary fibrosis resulting from STING gain-of-function autoinflammationF30HL154674 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, KEVIN MINGJIE · 2020 to 2022
$114kNHLBI NIH HHS F30 HL154674NHLBI NIH HHS K99 HL159258NHLBI NIH HHS R01 HL118100NHLBI NIH HHS R01 HL141377NHLBI NIH HHS R01 HL165718NHLBI NIH HHS R01 HL165787NIAID NIH HHS R01 AI128358NIAID NIH HHS R21 AI178978NIAID NIH HHS T32 AI132152NIAMS NIH HHS R01 AR055634NIGMS NIH HHS T32 GM107000
Abstract
Patients afflicted with Stimulator of interferon gene (STING) gain-of-function mutations frequently present with debilitating interstitial lung disease (ILD) that is recapitulated in mice expressing the STING
Indexed as
Endothelial CellsGain of Function MutationLungMembrane ProteinsAnimalsHumansLung Diseases, InterstitialLymphocytesMiceMice, Inbred C57BLSTING ProteinMembrane ProteinsSting1 protein, mouseSTING Proteinautoinflammationbronchus-associated lymphoid tissueconditional knockinCP: Immunologyendothelial cellsinnate immunityinterstitial lung diseaseSAVISTINGstromal cell immunity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.