Evidence map›Paper›PMID 38625489›Full record

ArticleJournal of autism and developmental disorders2025

Correlates of Impairment and Growth in Families of Young Autistic Children.

Kristen T MacKenzie, Mario J Crown, Jessie B Northrup, Elizabeth Rutenberg, Amy G Hartman, Carla A Mazefsky

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Identifying Unique Subgroups of Emotional and Behavioral Presentations in a Large Inpatient and Community Sample of Autistic Youth.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  2. Article
  3. Review and Developmental Model: Early Childhood Emotion Regulation and Co-Regulation in Autism.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
    Review
  4. Our Challenges, Our Solutions: The Impact of Autism on Families.Journal of autism and developmental disorders · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kristen T MacKenzieSchool of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. mackenzi@pitt.edu.ORCID http://orcid.org/0000-0002-7608-1295
Mario J CrownSchool of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-1356-0827
Jessie B NorthrupSchool of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-9863-9352
Elizabeth RutenbergSchool of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0009-0004-1650-1237
Amy G HartmanSchool of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-0737-8375
Carla A MazefskySchool of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-7467-0902
University of Pittsburgh · US

Funding

Change-sensitive Measurement of Emotion Dysregulation in ASDR01HD079512 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Carla A Mazefsky · 2014 to 2026
$6.3M
National Institute of Child Health and Human Development R01HD079512NICHD NIH HHS R01 HD079512
6 · The paper itself

Abstract

The purpose of this project was to investigate potential correlates of family life impairment in families of young autistic children. This project incorporated measures of specific child and parent challenges in addition to a commonly used unidimensional measure of autism characteristics. In this way, we could assess whether such challenges explain variance in family life impairment, and whether their inclusion diminish associations between autism characteristics and family life impairment. Cross-sectional data were collected from 564 parents of autistic children aged 2 to 5 years who participated in a larger online study. Participants completed measures on child characteristics (autism characteristics, emotion dysregulation, speaking ability, flexibility, and sleep problems), parent depression, and family life impairment, using the Family Life Impairment Scale (FLIS). Multiple linear regression models were generated to examine whether any of the independent variables were associated with the four domains of the FLIS. Models controlled for child age and sex, parent education, and single-parent homes. All independent variables were associated with impairment in one or more FLIS domains. None of the primary independent variables were significantly associated with positive growth. More overt characteristics and behaviors (e.g., autism characteristics, reactivity, speaking ability, and flexibility) were associated with impairment in domains that reflected a family's ability to navigate the community. However, sleep challenges and parent and child emotional difficulties were most strongly associated with parent impairment. Findings suggests that families may have different needs across contexts and provide new avenues through which they might be better supported.

Indexed as

Autistic DisorderFamilyParentsAdultChild, PreschoolCross-Sectional StudiesDepressionFemaleHumansMaleSleep Wake DisordersAutismFamily impairmentFamily lifeYoung children

Identifiers

PMID38625489
PMCPMC12445369
OpenAlexW4394849341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.