Evidence map›Paper›PMID 38625388›Full record

GuidelineEuropean journal of pediatrics2024

European expert guidance on management of sleep onset insomnia and melatonin use in typically developing children.

Oliviero Bruni, Maria Breda, Lino Nobili, Ingo Fietze, Oscar Ramon Sans Capdevila, Claude Gronfier

Open access · hybridAbstract readPractice GuidelineReview
In one paragraph

Guideline in European journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Early childhood insomnia phenotypes and temperament: a theoretical review with clinical implications for precision assessment and treatment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Review
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Melatonin supplementation: new insights into health and disease.Sleep & breathing = Schlaf & Atmung · 2025
    Review
  11. Bedtime routine.Sleep and biological rhythms · 2024
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 5 countries.

Oliviero BruniDepartment of Developmental and Social Psychology, Sapienza University of Rome, Rome, Italy. oliviero.bruni@uniroma1.it.ORCID http://orcid.org/0000-0003-2207-1398
Maria BredaDepartment of Psychology, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-6987-0491
Lino NobiliDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, University of Genoa, Genoa, Italy.ORCID http://orcid.org/0000-0001-9317-5405
Ingo FietzeInterdisciplinary Center of Sleep Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-5567-5206
Oscar Ramon Sans CapdevilaSleep Unit at the Sant Joan de Déu Children's Hospital in Barcelona, Barcelona, Spain.ORCID http://orcid.org/0009-0004-9766-8716
Claude GronfierLyon Neuroscience Research Center (CRNL), Neurocampus, Waking Team, Inserm UMRS 1028, CNRS UMR 5292, Université Claude Bernard Lyon 1, Université de Lyon, 69000, Lyon, France.ORCID http://orcid.org/0000-0002-6549-799X
Sapienza University of Rome · ITHospital Sant Joan de Déu Barcelona · ESIstituto Giannina Gaslini · ITUniversité Claude Bernard Lyon 1 · FRZigong First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleeping problems are prevalent among children and adolescents, often leading to frequent consultations with pediatricians. While cognitive-behavioral therapy has shown effectiveness, especially in the short term, there is a lack of globally endorsed guidelines for the use of pharmaceuticals or over-the-counter remedies in managing sleep onset insomnia. An expert panel of pediatric sleep specialists and chronobiologists met in October 2023 to develop practical recommendations for pediatricians on the management of sleep onset insomnia in typically developing children. When sleep onset insomnia is present in otherwise healthy children, the management should follow a stepwise approach. Practical sleep hygiene indications and adaptive bedtime routine, followed by behavioral therapies, must be the first step. When these measures are not effective, low-dose melatonin, administered 30-60 min before bedtime, might be helpful in children over 2 years old. Melatonin use should be monitored by pediatricians to evaluate the efficacy as well as the presence of adverse effects.    Conclusion: Low-dose melatonin is a useful strategy for managing sleep onset insomnia in healthy children who have not improved or have responded insufficiently to sleep hygiene and behavioral interventions.

Indexed as

MelatoninSleep Initiation and Maintenance DisordersAdolescentCentral Nervous System DepressantsChildChild, PreschoolEuropeHumansSleep HygieneCentral Nervous System DepressantsMelatoninAdolescentsChildrenInsomniaMelatoninPediatricians

Identifiers

PMID38625388
PMCPMC11192690
OpenAlexW4394844575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.