ReviewSystems microbiology and biomanufacturing2022
Bioreactor control systems in the biopharmaceutical industry: a critical perspective.
Review in Systems microbiology and biomanufacturing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Biocatalytic and biogenic pathways for sustainable nanoparticle synthesis: mechanisms, monitoring, and circular bioeconomy integration.Bioprocess and biosystems engineering · 2026Review
- Color-Changing Hydrogels for Visual pH Monitoring of Confined Living Systems.ACS measurement science au · 2026Article
- Current Regulatory Frameworks for Bioactive Inputs in Plant Systems Producing Pharmaceutically Important Compounds.Plants (Basel, Switzerland) · 2026Review
- Industrial Bioreactor Technologies for Modern Biomanufacturing: Recent Applications in Microbial, Mammalian, and Plant-Based Systems.Molecular biotechnology · 2026Review
- Microbial and Insect Gut-Mediated Polystyrene Microplastic Degradation for Environmental Remediation Applications.Nanomaterials (Basel, Switzerland) · 2026Review
- An IoT-Enabled Modular 3D Bioreactor for Vascular Tissue Engineering: Design, Fabrication, and Biological Validation.Bioengineering (Basel, Switzerland) · 2026Article
- Toward Sustainable Testosterone Manufacturing: Green Chemistry and Microbial Biotransformation Approaches.International journal of molecular sciences · 2026Review
- Spatially-resolved optical monitoring of bioreactor cell growth.Biomedical optics express · 2026Article
- Article
- Compression bioreactor for cultured meat.Current research in food science · 2026Article
- Conductive Covalent Organic Frameworks as Chemiresistive Sensor Arrays for the Detection and Differentiation of Gasotransmitters.Journal of the American Chemical Society · 2025Article
- Article
- Embedded IoT Design for Bioreactor Sensor Integration.Sensors (Basel, Switzerland) · 2024Article
- Unveiling the potential of specific growth rate control in fed-batch fermentation: bridging the gap between product quantity and quality.World journal of microbiology & biotechnology · 2024Review
- Review
- An Overview of Biosimilars-Development, Quality, Regulatory Issues, and Management in Healthcare.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Graphing the Green route: Enzymatic hydrolysis in sustainable decomposition.Current research in microbial sciences · 2024Review
- Ergot alkaloid control in biotechnological processes and pharmaceuticals (a mini review).Frontiers in toxicology · 2024Review
- Multispecies Bacterial Biofilms and Their Evaluation Using Bioreactors.Foods (Basel, Switzerland) · 2023Review
- A Floating Capsule Electrochemical System for In Situ and Multichannel Ion-Selective Sensing.Biosensors · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Industrial-scale bioprocessing underpins much of the production of pharmaceuticals, nutraceuticals, food, and beverage processing industries of the modern world. The profitability of these processes increasingly leverages the economies of scale and scope that are critically dependent on the product yields, titers, and productivity. Most of the processes are controlled using classical control approaches and represent over 90% of the industrial controls used in bioprocessing industries. However, with the advances in the production processes, especially in the biopharmaceutical and nutraceutical industries, monitoring and control of bioprocesses such as fermentations with GMO organisms, and downstream processing has become increasingly complex and the inadequacies of the classical and some of the modern control systems techniques is becoming apparent. Therefore, with increasing research complexity, nonlinearity, and digitization in process, there has been a critical need for advanced process control that is more effective, and easier process intensification and product yield (both by quality and quantity) can be achieved. In this review, industrial aspects of a process and automation along with various commercial control strategies have been extensively discussed to give an insight into the future prospects of industrial development and possible new strategies for process control and automation with a special focus on the biopharmaceutical industry. Supplementary Information: The online version contains supplementary material available at 10.1007/s43393-021-00048-6.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.