Evidence map›Paper›PMID 38624246›Full record

ReviewPhysiology (Bethesda, Md.)2024

Neural Processing without O

Lara Amaral-Silva, Joseph Santin

Open access · greenAbstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Brain-derived ketone bodies can replace glucose to power neural function.bioRxiv : the preprint server for biology · 2026
    Article
  4. Frogs uncouple neural activity from oxygen consumption after hibernation.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Lara Amaral-SilvaDepartment of Biology, Wake Forest University, Winston-Salem, North Carolina, United States.ORCID 0000-0001-6273-3240
Joseph SantinDivision of Biology, University of Missouri, Columbia, Missouri, United States.ORCID 0000-0003-1308-623X
University of Missouri · USWake Forest University · US

Funding

Homeostatic plasticity mechanisms regulate behavior in vivoR01NS114514 · NINDS · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI Joseph M Santin · 2021 to 2026
$1.5M
HHS | National Institutes of Health (NIH) R01NS114514NINDS NIH HHS R01 NS114514
6 · The paper itself

Abstract

Neuronal activity requires a large amount of ATP, leading to a rapid collapse of brain function when aerobic respiration fails. Here, we summarize how rhythmic motor circuits in the brain stem of adult frogs, which normally have high metabolic demands, transform to produce proper output during severe hypoxia associated with emergence from hibernation. We suggest that general principles underlying plasticity in brain bioenergetics may be uncovered by studying nonmammalian models that face extreme environments, yielding new insights to combat neurological disorders involving dysfunctional energy metabolism.

Indexed as

Energy MetabolismGlucoseAnimalsBrainBrain StemHibernationHumansHypoxiaNeuronsOxygenGlucoseOxygenamphibianbrainhypoxiaischemianeuron

Identifiers

PMID38624246
PMCPMC11573265
OpenAlexW4394836744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.