Evidence map›Paper›PMID 38624230›Full record

ArticleJournal of virology2024

The role of HPV11 E7 in modulating STING-dependent interferon β response in recurrent respiratory papillomatosis.

Lijuan Chen, Huiying Hu, Yufei Pan, Yuanyuan Lu, Mengyuan Zhao, Yun Zhao, Lixin Wang, Kai Liu, Zhenkun Yu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lijuan Chen *Department of Otolaryngology-Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.ORCID 0000-0002-0890-9994
Huiying Hu *Department of Otolaryngology-Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Yufei Pan *Department of Otolaryngology-Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Yuanyuan LuDepartment of Otolaryngology-Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Mengyuan ZhaoDepartment of Otolaryngology-Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Yun ZhaoNanjing Medical Key Laboratory of Laryngopharynx-Head and Neck Oncology, Nanjing, Jiangsu, China.
Lixin WangNanjing Medical Key Laboratory of Laryngopharynx-Head and Neck Oncology, Nanjing, Jiangsu, China.
Kai LiuDepartment of Otolaryngology-Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.ORCID 0000-0002-6947-6758
Zhenkun YuDepartment of Otolaryngology-Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.ORCID 0009-0004-7648-0538
Nanjing Medical University · CN

Funding

The Foundation of Nanjing Medical University and Academic program Development of Jiangsu Higher Education Institutions NMUB20220141The Jiangsu Provincial Commission of Health and Family Planning Funding K2019015The National Natural Science Foundation of Jiangsu BK20231124
6 · The paper itself

Abstract

Recurrent respiratory papillomatosis (RRP) is a rare benign tumor caused mainly by the infection of the respiratory tract epithelial cells by the human papillomavirus (HPV) type 6/11. However, the specific mechanisms underlying the inhibition of the host's innate immune response by HPV remain unclear. For this purpose, we employed single-cell RNA sequencing to analyze the states of various immune cells in RRP samples post-HPV infection and utilized a cellular model of HPV infection to elucidate the mechanisms by which HPV evades the innate immune system in RRP. The results revealed distinct immune cell heterogeneity in RRP and demonstrated that HPV11 E7 can inhibit the phosphorylation of the stimulator of interferon genes protein, thereby circumventing the body's antiviral response.

Indexed as

Human papillomavirus 11Papillomavirus E7 ProteinsPapillomavirus InfectionsRespiratory Tract InfectionsAdultEpithelial CellsFemaleHumansImmune EvasionImmunity, InnateInterferon-betaMacrophagesMaleMembrane ProteinsOncogene Proteins, ViralE7 protein, human papillomavirus 11Interferon-betaMembrane ProteinsOncogene Proteins, ViralPapillomavirus E7 ProteinsHPV11E7immunomodulationRRPscRNA‐SeqSTING

Identifiers

PMID38624230
PMCPMC11092327
OpenAlexW4394844639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.