Evidence map›Paper›PMID 38624229›Full record

ArticleJournal of virology2024

Genes involved in the limited spread of SARS-CoV-2 in the lower respiratory airways of hamsters may be associated with adaptive evolution.

Kosuke Takada, Yasuko Orba, Yurie Kida, Jiaqi Wu, Chikako Ono, Yoshiharu Matsuura, So Nakagawa, Hirofumi Sawa, Tokiko Watanabe

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Kosuke TakadaDepartment of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.ORCID 0009-0002-7951-8402
Yasuko OrbaDivision of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan.
Yurie KidaDepartment of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Jiaqi WuDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Chikako OnoLaboratory of Virus Control, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Yoshiharu MatsuuraLaboratory of Virus Control, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
So NakagawaDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.ORCID 0000-0003-1760-3839
Hirofumi SawaOne Health Research Center, Hokkaido University, Sapporo, Hokkaido, Japan.
Tokiko WatanabeDepartment of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.ORCID 0000-0001-6461-5379
The University of Osaka · JPHealth Sciences University of Hokkaido · JPNational Institute of Genetics · JPTokai University · JP

Funding

Japan Agency for Medical Research and Development (AMED) JP19fk018113, JP223fa627002h, 22gm1610010h0001Japan Agency for Medical Research and Development (AMED) JP20fk0108281, JP19fk0108113, JP20pc0101047Japan Agency for Medical Research and Development (AMED) JP20fk0108401, JP21fk0108493Japan Agency for Medical Research and Development (AMED) JP23wm0125008, JP223fa627005MEXT | Japan Science and Technology Agency (JST) JPMJCR20H6MEXT | Japan Science and Technology Agency (JST) JPMJMS2025MEXT | Japan Society for the Promotion of Science (JSPS) 16H06429, 16K21723, 16H06434, JP22H02521MEXT | Japan Society for the Promotion of Science (JSPS) 22K15469, 21J01036MEXT | Japan Society for the Promotion of Science (JSPS) JP16K21723, JP16H06432MEXT | Japan Society for the Promotion of Science (JSPS) JP21H02736Takeda Science Foundation (TSF)
6 · The paper itself

Abstract

Novel respiratory viruses can cause a pandemic and then evolve to coexist with humans. The Omicron strain of severe acute respiratory syndrome coronavirus 2 has spread worldwide since its emergence in late 2021, and its sub-lineages are now established in human society. Compared to previous strains, Omicron is markedly less invasive in the lungs and causes less severe disease. One reason for this is that humans are acquiring immunity through previous infection and vaccination, but the nature of the virus itself is also changing. Using our newly established low-volume inoculation system, which reflects natural human infection, we show that the Omicron strain spreads less efficiently into the lungs of hamsters compared with an earlier Wuhan strain. Furthermore, by characterizing chimeric viruses with the Omicron gene in the Wuhan strain genetic background and

Indexed as

COVID-19Evolution, MolecularSARS-CoV-2AnimalsCricetinaeLungMesocricetusanimal modelscoronavirusevolution

Identifiers

PMID38624229
PMCPMC11092350
OpenAlexW4394844392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.