Evidence map›Paper›PMID 38624209›Full record

ArticlemBio2024

Differential stability of Gcn4p controls its cell-specific activity in differentiated yeast colonies.

Libuše Váchová, Vítězslav Plocek, Jana Maršíková, Stanislava Rešetárová, Ladislava Hatáková, Zdena Palková

Open access · goldAbstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Libuše Váchová *Institute of Microbiology of the Czech Academy of Sciences, BIOCEV, Prague, Czech Republic.ORCID 0000-0002-8143-6054
Vítězslav Plocek *Faculty of Science, Charles University, BIOCEV, Prague, Czech Republic.ORCID 0000-0003-0459-2771
Jana Maršíková *Faculty of Science, Charles University, BIOCEV, Prague, Czech Republic.ORCID 0000-0003-3012-5536
Stanislava RešetárováInstitute of Microbiology of the Czech Academy of Sciences, BIOCEV, Prague, Czech Republic.ORCID 0009-0008-6878-2930
Ladislava HatákováFaculty of Science, Charles University, BIOCEV, Prague, Czech Republic.
Zdena Palková *Faculty of Science, Charles University, BIOCEV, Prague, Czech Republic.ORCID 0000-0002-0864-8042
Charles University · CZCzech Academy of Sciences, Institute of Microbiology · CZ

Funding

Czech Academy of Sciences RVO 61388971GAUK 460214MEYS LTAUSA18162MEYS LTC20036
6 · The paper itself

Abstract

Gcn4p belongs to conserved AP-1 transcription factors involved in many cellular processes, including cell proliferation, stress response, and nutrient availability in yeast and mammals. AP-1 activities are regulated at different levels, such as translational activation or protein degradation, which increases the variability of regulation under different conditions. Gcn4p activity in unstructured yeast liquid cultures increases upon amino acid deficiency and is rapidly eliminated upon amino acid excess. Gcn2p kinase is the major described regulator of Gcn4p that enables

Indexed as

Basic-Leucine Zipper Transcription FactorsGene Expression Regulation, FungalSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsProtein BiosynthesisProtein Serine-Threonine KinasesProtein StabilityProteolysisBasic-Leucine Zipper Transcription FactorsGCN2 protein, S cerevisiaeGCN4 protein, S cerevisiaeProtein Serine-Threonine KinasesSaccharomyces cerevisiae Proteinscell-specific regulationdifferentiated coloniesproteasomal degradationSaccharomyces cerevisiaespatially structured populationstranscription factoryeast

Identifiers

PMID38624209
PMCPMC11077963
OpenAlexW4394844133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.